Evaluation of Radio-Protective Effects of N-Acetylcysteine on Radiation-Induced Lethality in Mice

Introduction It has long been known that ionizing radiation can lead to detrimental effects in normal cells. In this light, Radioprotective chemicals have been used to decrease morbidity or mortality caused by ionizing irradiation. This study aimed to evaluate the radio-protective effect of N-acetylcysteineagainst radiation-induced mortality in male mice. Materials and Methods 52 healthy male mice were divided into four groups including NAC before irradiation (1), irradiation (2), NAC after irradiation (3) NAC before irradiation (4) and control. Three groups were treated orally with 100 mg/ kg of NAC. Gamma irradiation was performed at 8 Gy using a Co-60 machine. Kaplan-Meier method and the log-rank test were performed, using SPSS version 16. The significance level was considered to be 0.05. Results The statistical analysis revealed a significant difference between the test and control groups (P