نتایج جستجو برای: Radioprotective

تعداد نتایج: 1071  

Journal: :International journal of radiation biology and related studies in physics, chemistry, and medicine 1971
I Mustea Z Uray

The redox potential of spleen tissue in aiao was measured, and changes were observed after the administration of radioprotective drugs with reducing properties (aminothiols, dimercaptans, hydrazine derivatives, glucose, sulphites). The redox potential can be regarded as an indicator of the level of the energy metabolism of a tissue. The depression of the energy metabolism could be correlated wi...

Journal: :Blood 1991
K G Waddick C W Song L Souza F M Uckun

The purpose of the present study was to evaluate and compare the in vivo radioprotective effects of pre-total body irradiation (TBI) conditioning with recombinant granulocyte colony-stimulating factor (rG-CSF) and recombinant granulocyte-macrophage CSF (rGM-CSF) in a large series of lethally and supralethally irradiated mice. Also analyzed were the radioprotective effects of simultaneous as wel...

Journal: :Acta medica Okayama 1987
A Nishimura K Aono

Protection of Escherichia coli NIHJ and C57BL mice from the effects of 60Co gamma-rays provided by S-alk(en)yl-L-cysteines and their hydantoin derivatives was examined. E. coli (10(6) cells/ml) suspended in a 20 mM aqueous solution of one of the drugs was irradiated with 60 Gy of gamma-rays. Five week-old male mice were exposed to 5.0-9.5 Gy of gamma-rays after a single intraperitoneal injectio...

2015
Mikhail V. Vasin Igor B. Ushakov

This review gives a comparative evaluation of the radioprotective properties and the therapeutic index (TI) of radioprotectors from various pharmacological group in experiments on both small and large animals. It presents a hypothesis explaining the decrease in the TI of cystamine and 5-methoxytryptamine (mexamine), and the retention of that of α1-adrenomimetic indralin, and also compares the e...

Journal: :Mutagenesis 2005
Tung-Kwang Lee Roberta M Johnke Ron R Allison Kevin F O'Brien Larry J Dobbs

A majority of potential radioprotective synthetic compounds have demonstrated limited clinical application owing to their inherent toxicity, and thus, the seeking of naturally occurring herbal products, such as ginseng, for their radioprotective capability has become an attractive alternative. In general, ginseng refers to the roots of the species of the genus Panax. As a medicinal herb, ginsen...

2016
Jianru Pan Huocong He Ying Su Guangjin Zheng Junxin Wu Shutao Liu Pingfan Rao

Superoxide dismutase (SOD) fusion of TAT was proved to be radioprotective in our previous work. On that basis, a bifunctional recombinant protein which was the fusion of glutathione S-transferase (GST), SOD, and TAT was constructed and named GST-TAT-SOD. Herein we report the investigation of the cytotoxicity, cell-penetrating activity, and in vitro radioprotective effect of GST-TAT-SOD compared...

Journal: :International journal of radiation research 2022

Radioprotective effects of ethanolic extracts Gongronema latifolium leaf against radiation induced oxidative stress in Wistar albino Rats

Journal: :Journal of radiation research 2010
Genro Kashino Yong Liu Minoru Suzuki Shin-ichiro Masunaga Yuko Kinashi Koji Ono Keizo Tano Masami Watanabe

The radioprotective effects of dimethyl sulfoxide (DMSO) have been known for many years, and the suppression of hydroxyl (OH) radicals induced by ionizing radiation has been thought to be the main cause of this effect. However, the DMSO concentration used was very high, and might be toxic, in earlier studies. In the present study, we administered a lower, non-toxic concentration (0.5%, i.e., 64...

2018
Hyun Mi Kim Suk Hee Kim Bo Sun Kang

BACKGROUND/OBJECTIVES Exposure of the normal lung tissue around the cancerous tumor during radiotherapy causes serious side effects such as pneumonitis and pulmonary fibrosis. Radioprotectors used during cancer radiotherapy could protect the patient from side effects induced by radiation injury of the normal tissue. Delphinidin has strong antioxidant properties, and it works as the driving forc...

Journal: :YAKUGAKU ZASSHI 1963

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