Triterpenes and steroids from Euphorbia denticulate Lam. with Anti-Herpes Symplex virus activity

Authors

  • Hojjatollah Saeedi Department of Biology, Faculty of Science, University of Isfahan, Isfahan, Iran.
  • Loghman Salimzadeh Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.
  • Marzieh Mohammadi-Kamalabadi MSc student of Microbiology, Islamic Azad University, Falavarjan Branch, Young Researchers and Elites Club, Isfahan, Iran.
  • Mohammad Reza Rahimnejad Department of Biology, Faculty of Science, University of Isfahan, Isfahan, Iran.
  • Sara Shamsabadipour Isfahan Pharmaceutical Sciences Research Center. Isfahan University of Medical Sciences, Isfahan, I.R. Iran.
  • Seyed Majid Ayatollahi Phytochemistry Research Center and School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Abstract:

In this research, dried acetone:chloroform extract of aerial parts of E. denticulata as one of the endemic plants to Iran, afforded a number of triterpenes and steroids including: betulin, 24-methylene-cycloart-3-ol, cycloart-23Z-ene-3β,25-diol, cycloart-23Z-ene-3β,25-diol, ergosta-8,24-dien-3-ol (obtusifoliol) and beta-sitosterol which were reported for the first time from this plant. The structure of these compounds was elucidated by NMR and mass spectroscopic methods. The MTS assay was used to determine the toxicity and antiviral activity of betulin and (3β,23E)-Cycloarta-23-ene-3,25-diol. Betulin showed anti-HSV-1 activity with EC50 value of 84.37±0.02 µg/ml, and toxicity on normal vero cells with CC50 value of 660.718±0.072 µg/ml. (3β,23E)-Cycloarta-23-ene-3,25-diol showed antiviral effect with EC50 value of 86.63±0.03 µg/ml, and toxicity with CC50 value of 1089.21±0.25 µg/ml. The results revealed that these two compounds have the antiviral activity far below the CC50 value with selectivity index (CC50/EC50) values of 7.83, and 12.57, respectively.

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Journal title

volume 12  issue 4

pages  759- 767

publication date 2013-11-01

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