introduction: the regulation of neuroendocrine axis is one of the most important goals in the treatment of rheumatoid arthritis. disease modifying drugs such as chloroquine with low dose steroid is the first choice in clinical practice by some physicians. this combination therapy is evaluated by this study. methods: this survey is a prospective study on furty patients. variables for determining...

background: chronic obstructive pulmonary disease (copd) is a major health dilemma and cause of morbidity and mortality in either industrialized or developing countries and inhaled corticosteroids are widely used worldwide in these patients. in this systematic review, we aimed to analyze the effectiveness of these gents compared to placebo. methods: pubmed and google scholar literature search h...

introduction: boron possesses widespread properties and is important for human and animal nutrition. since boron is rapidly bioavailable, the objective of the present study was to determine whether acute (hourly or daily), and weekly supplementationcould have any significant biological effects on the synthesis of steroids as well as inflammatory biomarkers. methods: eight male volunteers partic...

background: enzyme linked immunosorbent assay (elisa) has been described as an alternative to radioimmunoassay for the mammalian and nonmammalian steroids detection. in this study, a simple and rapid elisa is described and validated for 4-pregnen-3,20, dione (progesterone). materials and methods: a general procedure for preparation of the acetylcholinesterase labelled steroid is described which...

breast cancer affects iranian women at least one decade younger than their counterparts in othercountries and the incidence of breast fibroadenoma is growing in the last two decades in tehran. thisstudy aimed to compare the ahr levels in premenopausal breast cancer and breast fibroadnemo withappropriate normal groups. possible associations of ahr with lifestyle and reproductive risk factorsand ...

background: androgenic-anabolic steroids (aas) are abused by a growing number of bodybuilders. this descriptive cross-sectional study was conducted to determine prevalence and patterns of aas use by bodybuilders in hamadan, western iran. methods: in this cross-sectional study, participants were recruited from five gym clubs in two area of hamadan (a total of 10 clubs). twenty-five bodybuilders ...

introduction hemophagocytic lymphohistiocytosis (hlh) is a heterogeneous group of clinical syndromes characterized by activation and subsequent uncontrolled non-malignant proliferation of t-lymphocytes, histiocytes and macrophages leading to a cytokine storm and manifesting as prolonged fever, organomegaly, cytopenia, hyperferritinemia and demonstrable hemophagocytosis in the bone marrow. concl...