Comparison between Fluconazole and Terbinafine in the treatment of Tinea corporis and Tinea cruris

Authors

  • Ali Akbar Shamsian Departments of Parasitology, School of Medicine, Mashhad University of Medical Sciences, Mashhad,
  • Elham Moghaddas Parasitology Department, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Kiarash Ghazvini Associated Professor of Microbiology, Antimicrobial Resistance Research Center, Department of Microbiology, School of Medicine,Mashhad University of Medical Sciences, Mashhad, Iran.
  • Masoud Shafiee General Physician, Health center, Mashhad University of Medical Sciences, Mashhad, Iran
  • Mohammad Javad Yazdanpanah Cutaneous Leishmaniasis Research Center, Department of Dermatology, School of Medicine, Mashhad University of Medical Sciences, Mashhad,
  • Mohammad Reza Hedayati-Moghadam Research Center for HIV/AIDS, HTLV and Viral Hepatitis, Iranian Academic Center for Education, Culture and Research (ACECR), Mashhad, IR Iran.
Abstract:

Objectives: This study aimed to compare the therapeutic efficacy of Terbinafine andFluconazole in terms of mycological cure in the treatment of Tinea corporis and Tineacruris. Method: In this clinical trial, 30 patients with T. corporis and T .cruris wereselected. Patients were divided into two groups by random selection. The first group wastreated with Fluconazole 150 mg weekly for four weeks and the second group wasadministered Terbinafine 250 mg daily for two weeks. The participants were followed uptill the end of the treatment and one month after treatment. Results: At the end of thetreatment, 64.3% of the subjects in Fluconazole group developed clinical and laboratoryresponses; while the second group developed 75% clinical and 81.3% laboratory cure.One month later, 64.3% in the Fluconazole group were cured, while in the other group,87.5% were cured. No patient had any side effect. Conclusion: Although, no significantdifference was observed between these two groups of patients in clinical and laboratoryaspect, as a result of lower price and easier consumption, it is suggested that Fluconazoleis more suitable for treatment of Tinea infections.

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Journal title

volume 2  issue 2

pages  105- 110

publication date 2015-07-01

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