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I report here an elderly woman receiving perphenazine together with terbinafine. After 1 week of terbinafine treatment she experienced extrapyramidal symptoms and, in particular, akathisia. Her symptoms did not disappear for 6 weeks, and so at 2 weeks prior to this most recent admission she had stopped taking terbinafine. However, these symptoms persisted for 3 weeks after discontinuing terbina...

Terbinafine is an allylamine antifungal agent. Its severe cutaneous adverse effects are rare, but toxic epidermal necrolysis, pustular drug eruption, acute generalized exanthematous pustulosis, Stevens-Johnson syndrome, and erythema multiforme had been reported. Terbinafine was also reported to induce flare-up of chronic psoriasis or development of pustular psoriasis. Here we report a psoriatic...

background and purpose: otomycosis is an acute, subacute or chronic fungal infection of the pinna, the external auditory meatus and the ear canal caused mainly by several species of saprophytic fungi. lamisil (terbinafine) is an allylamine antifungal agent, that is used both in the topical and oral administration for the treatment of dermatophytosis, cutaneous candidiasis, and the pityriasis ve...

Introduction: Recent epidemiological studies show that episodes due to non-albicans species of Candida (C) such as Candida tropicalis, C. glabrata, C, krusei, C. parapsilosis appear to be increasing in recurrent vulvovaginal candidiasis (RVVC). Increased use of the current antifungal drugs cause drug resistance among Candida species. In order to gain suitable antifungal therapy for this disease...

Previous studies evaluating short-term itraconazole and terbinafine therapy for onychomycosis have varied in protocol and size; this double-blind study enabled a large-scale, standardized, direct comparison. Patients with toenail onychomycosis were randomized to itraconazole 200 mg daily (n = 146) or terbinafine 250 mg daily (n = 146) for 12 weeks, with a 36-week follow-up. Mycological cure rat...

Objectives: The objectives of this study were to assess the efficacy oral monotherapy (Terbinafine) as compared combination drugs (Terbinafine and fluconazole) in treatment dermatophyte infections. Methods: Patients clinically diagnosed, potassium hydroxide (KOH) confirmed infections (n=235), recruited per inclusion criteria randomized into Group A (Tab. Terbinafine 6 mg/kg body weight daily) B...

Background: Dermatophytosis was a fungal infection caused by molds (dermatophytes). Dermatophytes are group of closely related filamentous fungi able to damage and utilize keratin found in the skin, hair, nails. Objective: To isolate species which cause resistant dermatophytosis, clinical types tinea, as well assess response different antifungal therapies.
 Patients Methods: Ninety-two pat...

The aim of this study was to evaluate the safety and efficacy of oral terbinafine (500 and 1000 mg day(-1)) in the treatment of cutaneous or lymphocutaneous sporotrichosis. A culture for Sporothrix schenckii was required for inclusion into this multicentre, randomized, double-blind, parallel-group study. Patients received either 250 mg b.i.d. or 500 mg b.i.d. oral terbinafine for up to a maximu...