dna intercalators and using them as anticancer drugs

نویسندگان

masoud karimi goftar

nasrollah moradi kor

zahra moradi kor

چکیده

many anticancer drugs in clinical use interact with dna through intercalation, which is process that starts with the transfer of the intercalating molecule from an aqueous environment to the hydrophobic space between two adjacent dna base pairs. in general, intercalatig agents are two types: monofunctional and bifunctional. monofunctional intercalators contain one intercalating unit and bifunctional intercalators (bis-intercalators) contain two intercalating units, normally cationic, separated by a spacer chain that must be long   enough to allow double intercalation taking into account the neighbour exclusion principle.

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عنوان ژورنال:
international journal of advanced biological and biomedical research

ناشر: casrp publishing company

ISSN 2383-2762

دوره 2

شماره 3 2014

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