نتایج جستجو برای: intercalator

تعداد نتایج: 371  

Journal: :international journal of advanced biological and biomedical research 2014
masoud karimi goftar nasrollah moradi kor zahra moradi kor

many anticancer drugs in clinical use interact with dna through intercalation, which is process that starts with the transfer of the intercalating molecule from an aqueous environment to the hydrophobic space between two adjacent dna base pairs. in general, intercalatig agents are two types: monofunctional and bifunctional. monofunctional intercalators contain one intercalating unit and bifunct...

Journal: :Biochemistry 2002
Kimberly D Copeland Marilena P Fitzsimons Robert P Houser Jacqueline K Barton

With the goal of developing artificial nucleases for DNA hydrolysis, metal-coordinating peptides have been tethered to a DNA-intercalating rhodium complex to deliver metal ions to the sugar-phosphate backbone. The intercalator, [Rh(phi)(2)bpy']Cl(3) [phi = 9,10-phenanthrenequinone diimine; bpy' = 4-(butyric acid)-4'-methyl-2,2'-bipyridine], provides DNA binding affinity, and a metal-binding pep...

Journal: :Frontiers in bioscience : a journal and virtual library 2006
Hakan Karadeniz Beste Gulmez Arzum Erdem Frantisek Jelen Mehmet Ozsoz Emil Palecek

A bis-intercalator echinomycin (ECHI) and a simple intercalator [Co(phen)3]3+ were used as a novel electrochemical redox indicators to detect DNA hybridization at gold electrodes (AuE). In order to minimize the nonspecific adsorption of oligonucleotides (ODN), the thiol-derivatized oligonucleotides were immobilized onto AuE in the first step, and the exposition of AuE to 6-mercapto-1-hexanol (M...

Journal: :Journal of the American Chemical Society 2004
Anne Petitjean Jacqueline K Barton

A novel bimetallic conjugate combining a rhodium intercalator that selectively binds DNA mismatches and a reactive cis-platinum analogue that targets DNA by coordination has been prepared. The site-selectivity of the bimetallic complex in forming coordination adducts is examined using mismatched and well-matched oligonucleotides of different sequences. The results indicate that through the bifu...

Journal: :Biochemistry 2010
Liang Xue Hongjuan Xi Sunil Kumar David Gray Erik Davis Paris Hamilton Michael Skriba Dev P Arya

Thermodynamic studies on the interactions between intercalator-neomycin conjugates and a DNA polynucleotide triplex [poly(dA).2poly(dT)] were conducted. To draw a complete picture of such interactions, naphthalene diimide-neomycin (3) and anthraquinone-neomycin (4) conjugates were synthesized and used together with two other analogues, previously synthesized pyrene-neomycin (1) and BQQ-neomycin...

Journal: :Chemical communications 2008
Ta-Sheng Andrew Tseng Judith N Burstyn

An intercalator-linked macrocycle 3,6-bis(dimethylamino)-10-(6-[1,4,7-triazacyclononane]hexyl) acridinium bromide was synthesized, its copper(ii) complex was prepared, and the DNA cleavage activity of this metal complex was compared to that of the intercalator-free (Cu[9]aneN(3))(2+) complex.

Journal: :The Journal of biological chemistry 1982
L A Zwelling D Kerrigan Y Pommier S Michaels A Steren K W Kohn

DNA strand breaks produced by damaging agents such as x-ray generally stimulate poly(adenosine diphosphoribose) (ADP-R) synthesis in mammalian cells. DNA intercalating agents induce the formation of strand breaks which are unusual in that they are associated with tightly or covalently bound protein. In order to determine whether the intercalator-induced strand breaks are associated with poly-(A...

2001
S. B. Cho J. S. Hong Y. K. Pak J. J. Pak

One of the important roles of a DNA sensor is the capability of detecting genetic diseases or mutations by analyzing DNA sequence. The electrochemical detection method can be simpler and cheaper than other methods available and hence this method was investigated in this paper. For a successful electrochemical detection, several aspects should be considered including chemical treatment of electr...

Journal: :Chemical communications 2003
Kerry P Mahon Rodrigo F Ortiz-Meoz Erin G Prestwich Shana O Kelley

A novel class of DNA cleavage agents are reported that derive activity from amino acids tethered to a photoactive intercalator.

Journal: :Cancer research 1983
Y Pommier L A Zwelling M R Mattern L C Erickson D Kerrigan R Schwartz K W Kohn

The free radical scavengers, dimethyl sulfoxide (Me2SO) and thiourea, were used to assess the role of free radicals in the production of intercalator-induced DNA breaks and cytotoxicity in mouse leukemia L1210 cells. Both agents decreased X-ray break production, and this decrease was comparable in magnitude to the degree of inhibition of X-ray-induced cell killing. By contrast, Me2SO increased ...

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