evaluation of efficacy of h. pylori eradication regimens in iran: a systematic review

background: treatment regimens for the eradication of h. pylori as suggested in western studies may not be applicable for iran. herein, we conduct a systematic review to ascertain the efficacy of eradication therapy regimens used for iranian patients and introduce the more successful treatment regimens for iranians. materials and methods: this review was a comprehensive search of english and farsi electronic databases conducted from june to september 2011.results: a total of 11 trials were included in our study. in these, there were 28 different eradication regimens studied. of the 28 regimens, 8 had an h. pylori eradication rate of over 85% and in 3 the eradication rate was greater than 90%. in iran, the regimens that contained amoxicillin-furazolidone or amoxicillin-clarithromycin for two weeks were the most effective for h. pylori eradication, although the furazolidone-based regimen was less expensive. conclusion: for first-line treatment, the amoxicillin-furazolidone-based regimen for 2 weeks is cost-effective for h. pylori eradication in iranian patients.