probiotics as a novel treatment for non-alcoholic fatty liver disease; a systematic review on the current evidences
نویسندگان
چکیده
context non-alcoholic fatty liver disease (nafld) is a chronic liver disease, with 5-10% of liver having extra fat. increase in its prevalence in all age groups is linked with obesity and type ii diabetes. the treatment of nafld remains controversial. a growing body of evidence suggests a relation between overgrowth of gut microbiota with nafld and non-alcoholic steatohepatitis (nash). the objective of this review is to provide an overview on experimental and clinical studies assessing all positive and negative effects of probiotics. evidence acquisition we made a critical appraisal on various types of documents published from 1999 to march 2012 in journals, electronic books, seminars, and symposium contexts including medline, pubmed, and cochrane central register of controlled trials databases. we used the key words: “non-alcoholic fatty liver disease, probiotics, non-alcoholic steatohepatitis, liver disease, and fatty liver”. results probiotics, as biological factors, control the gut microbiota and result in its progression. it is in this sense that they are suggestive of a new and a natural way of promoting liver function. correspondingly, limited evidence suggests that probiotics could be considered as a new way of treatment for nafld. conclusions various experimental studies and clinical trials revealed promising effects of probiotics in improving nafld; however given the limited experience in this field, generalization of probiotics as treatment of nafld needs substantiation through more trials with a larger sample sizes and with longer-term follow up.
منابع مشابه
more on current evidences on probiotics as a novel treatment for non-alcoholic fatty liver disease
متن کامل
Probiotics as a Novel Treatment for Non-Alcoholic Fatty Liver Disease; A Systematic Review on the Current Evidences
CONTEXT Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease, with 5-10% of liver having extra fat. Increase in its prevalence in all age groups is linked with obesity and Type II diabetes. The treatment of NAFLD remains controversial. A growing body of evidence suggests a relation between overgrowth of gut microbiota with NAFLD and non-alcoholic steatohepatitis (NASH). The obje...
متن کاملMore on Current Evidences on Probiotics as a Novel Treatment for Non-Alcoholic Fatty Liver Disease
In their recent article Kelishadi et al. (1) analyzed in a clear and concise way a number of key aspects of obesity-related NAFLD, deepening in particular the role of gut microflora and its potential therapeutic modulation by probiotics. From their paper it is apparent that most promises still derive from a relevant number of studies conducted in different NAFLD animal models. When interpreting...
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Introduction: Non-alcoholic fatty liver disease (NAFLD) is a condition in which triglycerides accumulate in liver cells without a history of alcohol consumption. Evidence has shown that auxiliary treatments, including the use of antioxidant compounds, can be effective in improving nonalcoholic fatty liver. Resveratrol is an antioxidant compound that has been shown to be beneficial in some disea...
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Introduction: Non-alcoholic fatty liver disease (NAFLD) is the accumulation of fat vacuoles in liver cells. It can progress to non-alcoholic steatohepatitis (NASH), which could eventually lead to liver cirrhosis and hepatocellular carcinoma. Until now, there is no effective treatment for these conditions, except managing through modifications in lifestyle and diet (including controlling weight)...
متن کاملtreatment of non-alcoholic fatty liver disease (nafld): a systematic review
â â no treatment has been proven to be effective in nonalcoholic fatty liver disease (nafld) and/or steatohepatitis (nash). numerous studies have addressed this issue. however conclusive recommenâdations cannot be drawn solely from the currently available studies. hence we performed this systematic review to determine which of the available therapeutic modalities are supported by adequate ev...
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عنوان ژورنال:
hepatitis monthlyجلد ۱۳، شماره ۴، صفحات ۰-۰
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