due to good biocompatibility, corrosion and mechanical properties, magnesium (mg) is considered promising degradable material for orthopedic applications. in this work, mg-mgznx (x= 1, 2, 3 and 4) nanocomposites scaffolds with different porosities were synthesized via powder metallurgy method. the microstructure, composition, in vitro corrosion and mechanical properties of porous magnesium-zinc...

We present a three-dimensional zinc-air microbattery with improved discharge rate and reduced internal resistance. The device is based on a multilayer, micron-scale, high surface area metallic scaffold ‘skeleton’. This scaffold consists of alternating copper and nickel layers supporting zinc as electrodeposited anode material. A proof-of-concept zinc-air microbattery based on this technology wa...

INVESTIGATION OF THE INFLUENCE ZINC OXID CONTENT AND SCAFFOLD MORPHOLOGY ON MECHANICAL PROPERTIES POLY(ε-CAPROLACTONE) / OXIDE NANOCAMPOSITE SCAFFOLDS

Magnesium has been recently recognized as a biodegradation metal for bone substitute application. In the present work, porous magnesium-zinc scaffolds were prepared by powder metallurgical process and nano hydroxyapatite (HAP) coating on the Mg-3Zn (wt.%) scaffold was prepared by pulse electrodeposition and alkali treatment processes to improve the corrosion resistance of scaffold. The results ...

We report here the design and synthesis of a new hybrid bis-anthracene-imidazolium salt, having pyridine scaffold. NMR studies dimer generation, as well complexation with zinc acetate were performed.

Small-molecule fluorescent sensors are versatile agents for detecting mobile zinc in biology. Capitalizing on the abundance of validated mobile zinc probes, we devised a strategy for repurposing existing intensity-based sensors for quantitative applications. Using solid-phase peptide synthesis, we conjugated a zinc-sensitive Zinpyr-1 derivative and a zinc-insensitive 7-hydroxycoumarin derivativ...

Early studies of the bacterial Fe-S cluster assembly system provided structural details for how the scaffold protein and the cysteine desulfurase interact. This work and additional work on the yeast and human systems elucidated a conserved mechanism for sulfur donation but did not provide any conclusive insights into the mechanism for iron delivery from the iron donor, frataxin, to the scaffold...

The RNA polymerase subunit RPB10 displays a high level of conservation across archaea and eukarya and is required for cell viability in yeast. Structure determination of this RNA polymerase subunit from Methanobacterium thermoautotrophicum reveals a topology, which we term a zinc-bundle, consisting of three alpha-helices stabilized by a zinc ion. The metal ion is bound within an atypical CX(2)C...

Hydrozirconation of 1-hexyne, the addition to in situ prepared N-acyliminium species, and ring-closing metathesis (RCM) were key steps in the preparation of a tricyclic isoindolinone scaffold. An unusual alkene isomerization process during the RCM was identified and studied in some detail. Chemical diversification for library synthesis was achieved by a subsequent alkene epoxidation and zinc-me...

Chitosan bears numerous properties, such as biocompatibility, biodegradability and non-toxicity making it suitable for use in different biomedical fields. Zinc (Zn) is required for fibroblasts proliferation and collagen synthesis as essential elements of wound healing. Its nanoparticles are well known for their capability to enhance wound healing by cell adhesion and migration improvement throu...