The interaction between zaleplon (ZAL) and different cyclodextrins in aqueous solutions was investigated by spectrofluorimetric and phase solubility studies. Stability constants determined by both methods showed that among natural cyclodextrins, β-cyclodextrin (βCD) formed the most stabile complex but its solubilizing efficiency was limited. Among βCD derivatives, the complex stability and solu...

Although estrogen replacement therapy may improve dampened endothelial function in postmenopausal women, the associated risk of breast and ovarian cancer has limited its long-term use. Identifying effective alternative remedy with less carcinogenicity is in serious demand. This study was designed to examine the effect of the phytoestrogen alpha-zearalanol (alpha-ZAL) on homocysteine-induced end...

Estrogen is known to provide robust protection of memory in postmenopausal women, but the fact that estrogen may increase the incidence of uterine and breast tumors has undoubtedly limited the clinical use of estrogen. In the present study, the effect of α-zearalanol (α-ZAL), a plant-derived phytoestrogen with low side-effect on uterine and breast, on memory has been evaluated in ovariectomized...

The aim of this research is to investigate the vasorelaxing effects and mechanisms involved in the phytoestrogen α-zearalanol (α-ZAL) in rat thoracic aortas rings. Intact or endothelium denuded rat thoracic aortas rings were put in individual organ chamber to observe the endothelium-dependent or independent vasorelaxing effects of α-ZAL (10-10-10-5 M). The thoracic aortas rings were pre-contrac...

A new layered organic-inorganic nanohybrid material, zinc-aluminum-3,4-dicholorophenoxyacetate (N3,4-D) in which an agrochemical, 3,4-dichlorophenoxyacetic acid (3,4-D), is intercalated into zinc-aluminum-layered double hydroxide (ZAL), was synthesized by coprecipitation method. A well-ordered nanomaterial was formed with a percentage loading of 53.5% (w/w). Due to the inclusion of 3,4-D, basal...

this study reviews the formations of the family in shahnameh; distribution of power in it; and its identity. therefore, we study the theoretical background related to the subject of the research, theories related to the topic of cultural theories of malinowski, radcliffe brown, ario and shlensky, ronard and proposed research and theoretical framework of the research were written according to th...

Layered double hydroxide (LDH) is an inorganic-organic nano-layered material that harbours drug between its two-layered sheets, forming a sandwich-like structure. It is attracting a great deal of attention as an alternative drug delivery (nanodelivery) system in the field of pharmacology due to their relative low toxic potential. The production of these nanodelivery systems, aimed at improving ...

Conodonts are the most important fossil remains from the largest Phanerozoic extinction as well as the mass extinction of the late Paleozoic and could be used for exact dating during this period. Triassic deposits located in the Elikah Formation contain exposures in most of the Alborz sections as well as the Zal section in northwestern Iran. In this study, the Elikah Formation was investigated ...

found around East-Pacific Rise hydrothermal vents is the giant tube-worm Riftia pachyptila Jones, 1981. This “autotrophic” animal is devoid of a digestive system and acquires metabolic energy from the oxidation of sulphide by chemolithoautotrophic bacteria that live symbiotically inside a specific, highly vascularized organ, the trophosome. Therefore, blood transport nutrients is a crucial issu...

Pre-osteoblast MC3T3-E1 cells were cultured in hyaluronic acid-modified chitosan/collagen/nano-hydroxyapatite (HA-CS/Col/nHAP) composite scaffolds and treated with phytoestrogen α-zearalanol (α-ZAL) to improve bone tissue formation for bone tissue engineering. Perfusion and dynamic strain were applied to three-dimensional (3D) cultured cells, which simulates mechanical microenvironment in bone ...