NEW DRUG APPROVALS Adzenys XR-ODT for ADHD The FDA has given the green light to Adzenys XR-ODT (Neos Therapeutics) for the treatment of attention -deficit/ hyperactivity disorder (ADHD) in patients 6 years of age and older. With this approval, the product is the first extended-release orally disintegrating tablet (ODT) for this indication. Adzenys XR-ODT contains amphetamine loaded onto a mixtu...

where (b) holds by applying chain rule successively, and (c) holds because conditioning reduces entropy. Note that, for a known exponential family distribution, H(Xr | Br(X)) is constant. For examples in a Gaussian, Dirichlet, Gamma, Wishart, Xr is also a function of Br(Xr), meaning H(Xr | Br(X)) = 0. For a Laplacian distribution, H(Xr | Br(X)) = H(Sign(Xr)) = 1. Therefore, we can conclude that...

We generated an expression construct consisting of the xylose reductase (XR) gene (xr) from Phanerochaete chrysosporium. Transformant X7 exhibited increased xylitol production and markedly higher XR activities than the wild-type strain. RT-PCR analysis demonstrated that the increased XR activity was associated with constant expression of the recombinant xr gene.

JPEG XR is considered as a lossy sample data compression scheme in the context of iris recognition techniques. It is shown that by optimising the JPEG XR quantisation strategy, JPEG XR default quantisation as well as JPEG2000 based iris recognition can be improved in terms of EER. The optimised JPEG XR quantisation strategy shows good performance across a wide range of iris feature extraction t...

INTRODUCTION Saxagliptin added to metformin extended release (XR) and uptitrated metformin XR were evaluated for their impact on daily glucose measurements and their tolerability in patients with type 2 diabetes mellitus (T2DM) inadequately controlled with metformin monotherapy. METHODS Patients aged 18-78 years on metformin 850-1,500 mg with glycated hemoglobin (HbA1c) 7.5-11.5% at screening...

AIM To investigate whether patients taking metformin for type 2 diabetes mellitus (T2DM) have improved glycaemic control without compromising tolerability by adding an agent with a complementary mechanism of action vs. uptitrating metformin. METHODS Adults with T2DM and glycated haemoglobin (HbA1c) between 7.0 and 10.5% receiving metformin extended release (XR) 1500 mg/day for ≥8 weeks were r...

CONTEXT Generalized anxiety disorder (GAD) is a chronic disorder in need of reliable data to guide long-term treatment. OBJECTIVES To assess the benefits of 6 and 12 months' treatment of GAD with venlafaxine hydrochloride extended release (XR) in patients who improved after 6 months' open-label venlafaxine XR treatment. DESIGN After 6 months' open-label venlafaxine XR treatment, improved pa...

OBJECTIVE Extended release (XR) and immediate release (IR) quetiapine have differing dosing, titration and plasma concentration profiles. The authors assessed whether the use of quetiapine XR and IR in schizophrenia spectrum disorders (SCZ) and bipolar disorder (BD) differ. DESIGN Retrospective non-interventional registry study. SETTING Secondary healthcare. PARTICIPANTS All SCZ and BD (I...