The effect of -158 (C>T) Xmn I polymorphism on expression of G-globin gene has been the subject of considerable interest. This study aims to determine the frequency of the G Xmn I polymorphism in thalassemia patients in Denizli province of Turkey. We studied Xmn I polymorphism in the DNA samples of 27 with -thalassemia major, 210 -thalassemia minor patients and 100 healthy subjects as the ...

The phenotype of E-beta-thalassemia is affected by several genetic factors. The aim of this study was to analyze severity of E-beta-thalassemia and correlate with HbE, HbF, E/F ratios, beta-mutation and Xmn I polymorphism. Thirty cases of E-beta-thalassemia (23 with childhood onset) were studied. HbE levels were quantitated by HPLC. Xmn1 polymorphism and beta-mutations were studied by PCR-RFLP ...

Background: Xmn-1 polymorphism of 𝜸Gglobin gene (HBG2) is a prominent quantitative trait loci (QTL) in β-thalassemia intermediate (β-TI). In current study, we evaluated the frequency of Xmn-1 polymorphism and its association with β-globin gene (HBB) alleles and Hb F level in β-TI patients in Sistan and Balouchestan province, south-east of Iran. Subjects and Methods: 45 β-TI patients were enroll...

From a Xenopus tailbud cDNA library, we obtained the cDNA for a novel cadherin which was named as XmN-cadherin (Xenopus maternally expressed neural cadherin). The cDNA consisted of 3690 bp and encoded 922 amino acid residues. XmN-cadherin preserved five extracellular cadherin motifs, a single transmembrane domain, and a cytoplasmic domain, and was closely related by its sequence to R- and N-cad...

background: xmn-1 polymorphism of y g globin gene ( hbg2 ) is a prominent quantitative trait loci (qtl) in β-thalassemia intermediate (β-ti). in current study, we evaluated frequency of xmn-1 polymorphism and its association with β-globin gene ( hbb ) alleles and hb f level in β-ti patients in sistan and balouchestan province, south-east of iran. methods: 45 β-ti patients were enrolled. hbb gen...

A method for the identification of three ixodid tick species; the cow tick (Boophilus annulatus), the camel tick (Hyalomma dromedarii) and the cattle tick (Hyalomma anatolicum excavatum) based on restriction enzyme analysis of the second internal transcribed spacer (ITS-2) in the nuclear ribosomal DNA was adopted. PCR products with MW 1375 bp, 1650 bp and 1835 bp from B. annulatus, H. dromedari...

Background and Objectives. To explore the role of cis-regulatory sequences within the β globin gene cluster at chromosome 11 on human γ globin gene expression related to Hb E allele, we analyze baseline hematological data and Hb F values together with β globin haplotypes in homozygous Hb E. Patients and Methods. 80 individuals with molecularly confirmed homozygous Hb E were analyzed for the β g...

background: xmn-1 polymorphism of