Factor XIII or "fibrin-stabilizing factor," is a transglutaminase circulates in the blood circulation as a hetero tetramer with two catalytic A subunits and two carrier B subunits. This important coagulation factor has a crucial role in clotting cascade and produces strong covalent bonds between soluble formed fibrin monomers during coagulation. This stable cross linked fibrin strands are resis...

background: factor xiii (fxiii) is a heterotetramer composing two subunits including fxiii-a and fxiii-b. several common gene variations were observed in fxiii-a gene with obvious ethnic difference. this study assessed pattern of tyr204phe as a common fxiii-a gene variation among iranian population. materials and methods: this study was conducted on eighty iranian unrelated individuals. genotyp...

Plasma and platelet factor XIII levels were measured in normal human donors and in a patient congenitally deficient in factor XIII. The purpose of these experiments was to study the role of platelet factor XIII in blood coagulation. On polyacrylamide disc electrophoresis, factor XIII activity in extracts of washed normal platelets appeared as a single peak. This peak was missing or very low whe...

congenital factor xiii deficiency is a very rare bleeding disorder, but because of the high rate of consanguineous marriages, it is common in sistan and baluchestan province of iran. the discovery of promoter hypermethylation of numerous mirnas in human diseases has demonstrated an epigenetic mechanism for aberrant mirna expression. the present study has analyzed methylation and expression stat...

Factor XIII is one of the twelve coagulation factors and also known as a fibrin-stabilizing factor. In 2012, we encountered a male RA patient with hemorrhagic factor XIII deficiency who had been treated with tocilizumab for two years. There are few reports regarding the relationship between tocilizumab (a humanized monoclonal antibody against the interleukin-6 receptor (IL-6R)) and factor XIII....

Type XIII collagen belongs to the group of transmembrane collagens. In this thesis the plasma membrane localisation and function of type XIII collagen have been studied using cell biological methods. Type XIII collagen was found to reside in focal adhesions. It appeared in these structures at a very early stage of their assembly and disappeared from them concurrently with focal adhesion protein...

Factor XIII (Fibrin-stabilizing factor) is a tetrameric structural pro-transglutaminase from the transglutaminase family. Factor XIII activity is associated with the structure of fibrin clot. Factor XIII turns into XIII-A, which is an active transglutaminase, in the result phase of coagulation cascade together with Ca and thrombin activation. The main aim of Factor XIIIA is to connect ε(δ-gluta...

In this paper, we present a new class of public key cryptosystems by modifying K(XII)SE(1)PKC [1], referred to as K(XIII)SE(1)PKC, and a particular class of K(XIII)SE(1)PKC, Kp(XIII)SE(1)PKC. We show that K(XIII)SE(1)PKC would improve both the coding rate and the security, compared with K(XII)SE(1)PKC. We also show that Kp(XIII)SE(1)PKC realizes the coding rate of exactly 1.0. In a sharp contra...

conclusions the case was fully investigated and diagnosed as a case with factor xiii deficiency causing such uncontrolled bleeding after extraction of a tooth. introduction factor xiii deficiency is a relatively rare hereditary bleeding disorder, which is usually found during infancy or early childhood. this condition may involve both genders within different races in an equal manner. its incid...