OBJECTIVES This study sought to investigate the relationship between tubular damage and worsening renal function (WRF) in chronic heart failure (HF) BACKGROUND: WRF is associated with poor outcome in chronic HF. It is unclear whether urinary tubular markers may identify patients at risk for WRF. METHODS In 2,011 patients with chronic HF, we evaluated the ability of urinary tubular markers (N-...

Objectives. To determine the prevalence, the clinical predictors, and the prognostic significances of Worsening Renal Function (WRF) in hospitalized patients with Acute Heart Failure (AHF). Methods. 394 consecutively hospitalized patients with AHF were evaluated. WRF was defined as an increase in serum creatinine of ≥0.3 mg/dL from baseline to discharge. Results. Nearly 11% of patients develope...

The aim of this study was to evaluate the ability of Neutrophil Gelatinase-Associated Lipocalin (NGAL) to predict clinically relevant worsening renal function (WRF) in acute heart failure (AHF). Plasma NGAL and serum creatinine changes during the first 4 days of admission were investigated in 1447 patients hospitalized for AHF and enrolled in the Placebo-Controlled Randomized Study of the Selec...

The Weather Research and Forecasting model (WRF) is a simulating system developed for atmospheric weather prediction. WRF model is used for both operational as well as research purposes. The need for accurate weather and climate simulation to be carried out in shorter time is increasing day by day, which leads to the acceleration of existing Numerical Weather Prediction (NWP) system. This paper...

INTRODUCTION AND OBJECTIVES Acute decompensated heart failure (ADHF) is a common cause of hospital admission and is associated with an increased risk of worsening renal function (WRF). The aims of this study were to investigate the incidence and predictors of WRF in patients admitted for ADHF and to assess the prognostic significance of WRF at 1 year. METHODS A retrospective analysis of data ...

AIMS Chronic kidney disease (CKD) and worsening renal function (WRF) have been associated with poor outcome in heart failure (HF). METHODS AND RESULTS Articles were identified by literature search of MEDLINE (from inception to 1 July 2012) and Cochrane. We included studies on HF patients and mortality risk with CKD and/or WRF. In a secondary analysis, we selected studies investigating predict...

AIMS Renal failure is a major challenge in treating heart failure (HF) patients. HF medication may deteriorate renal function, but the impact thereof on outcome is unknown. We investigated the effects of HF medication on worsening renal function (WRF) and the relationship to outcome. METHODS AND RESULTS This post-hoc analysis of TIME-CHF (NT-proBNP-guided vs. symptom-guided management in chro...

Introduction Conclusions References

BACKGROUND Data comparing effects of transient worsening renal function (WRFt) and persistent WRF (WRFp) on outcomes in patients hospitalized with acute heart failure (AHF) are lacking. We determined the characteristics of hospitalized AHF patients who experienced no worsening renal function (non-WRF), WRFt, or WRFp, and the relationship between cohorts and AHF-related outcomes. METHODS AND R...

A polar-optimized version of the fifth-generation Pennsylvania State University–National Center for Atmospheric Research Mesoscale Model (MM5) was developed to fill climate and synoptic needs of the polar science community and to achieve an improved regional performance. To continue the goal of enhanced polar mesoscale modeling, polar optimization should now be applied toward the state-of-the-a...