نتایج جستجو برای: wogonin

تعداد نتایج: 280  

Journal: :Archives of pharmacal research 2005
Jinhee Jang Kwan-Seog Sin Hyun Pyo Kim Haeil Park

A number of wogonin derivatives have been synthesized as congeners of wogonin and evaluated for their inhibitory activities of PGE2 production. Wogonin derivatives modified at the B ring of wogonin were obtained from 2,4-Dihydroxy-3,6-dimethoxyacetophenone (1) via several steps. Most wogonin derivatives exhibited much reduced inhibitory activities against COX-2 catalyzed PGE2 production compare...

2018
Jong-Suep Baek Young-Guk Na Cheong-Weon Cho

While wogonin has been known to have cytotoxicity against various cancer cells, its bioavailability and cytotoxicity are low due to its low water solubility. Therefore, wogonin-loaded solid lipid nanoparticles were fabricated using a hot-melted evaporation technique. The highest solubility of wogonin was observed in stearic acid. Hence, wogonin-loaded solid lipid nanoparticles were composed of ...

2017
Haiwei Zhang Chuang Ge Changhai Lin Lin Yi Jing Ran Xiaolong Shi Chao Tang Yongzhong Wu Weiqi Nian

Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are widely used as targeted chemotherapeutic drugs in the treatment of advanced non-small cell lung cancer (NSCLC). However, acquired resistance against TKIs caused by T790M mutation of EGFR has become a major clinical problem. In this study, we assessed whether the combination of wogonin, a natural monoflavonoid, and ico...

Journal: :Oncology reports 2015
Chengjun Hu Maozhong Xu Rujuan Qin Weifeng Chen Xin Xu

Wogonin is a flavonoid isolated from Scutellaria baicalensis root and has multiple pharmacological effects, including anticancer effects. Recent studies have shown that wogonin induces cell cycle arrest and reverses multi-drug resistance in the human K562 leukemia cell line. However, its pharmacological function in the apoptosis of leukemia cells remains unknown. Therefore, we hypothesized that...

2017
Weiming Xiao Min Yin Keyan Wu Guotao Lu Bin Deng Yu Zhang Li Qian Xiaoqing Jia Yanbing Ding Weijuan Gong

Wogonin exerts anti-tumour activities via multiple mechanisms. We have identified that high-dose wogonin (50 or 100 mg/kg) could inhibit the growth of transplanted tumours by directly inducing tumour apoptosis and promoting DC, T and NK cell recruitment into tumour tissues to enhance immune surveillance. However, wogonin (20-50 μM) ex vivo prevents inflammation by inhibiting NF-κB and Erk signa...

2017
Xuefen Xu Xiaobo Zhang Yi Zhang Lin Yang Yicheng Liu Shaoliang Huang Lu Lu Lingyi Kong Zhiyu Li Qinglong Guo Li Zhao

Constitutive NF-E2-related factor 2 (Nrf2, NFE2L2) activation has been recently reported to play a pivotal role in enhancing cell survival and resistance to anticancer drugs in many tumors. Wogonin had strong reversal potency via reduction of Nrf2 mRNA in Adriamycin (ADR)-induced resistant human chronic myelogenous leukemia (CML) K562/A02, but the mechanism of reduction of Nrf2 mRNA was still u...

2016
Shao-Jun Li Shi-Jie Sun Jie Gao Fu-Bo Sun

Wogonin is considered to be an inhibitor of myeloid cell leukemia 1 and B-cell lymphoma 2, and a potential antitumor drug due to its ability to induce apoptosis in certain cancer cells; however, few previous studies have reported on wogonin-induced autophagy. The aim of the present study was to investigate the influence of wogonin on autophagy in human pancreatic cancer cells (HPCCs), elucidate...

Journal: :Oncology reports 2012
Fan He Qiong Wang Xue-Lian Zheng Jia-Qi Yan Lan Yang Hong Sun Li-Na Hu Yong Lin Xia Wang

Chemoresistance to cisplatin is a major limitation of cisplatin-based chemotherapy in the clinic. The combination of cisplatin with other agents has been recognized as a promising strategy to overcome cisplatin resistance. Previous studies have shown that wogonin (5,7-dihydroxy-8-methoxyflavone), a flavonoid isolated from the root of the medicinal herb Scutellaria baicalensis Georgi, sensitizes...

2017
Jiang Ruibin Jin Bo Wan Danying Zhu Chihong Feng Jianguo Gu Linhui

Background Wogonin is a plant monoflavonoid and has been reported to induce apoptosis of cancer cells and show inhibitory effect on cancer cell growth. However, the detailed and underlying molecular mechanisms are not elucidated. In this study, we investigated the molecular and biological effects of wogonin in human ovarian A2780 cancer cells. Materials and Methods We determined the effects o...

2014
Md. Asaduzzaman Sikder Hyun Jae Lee Jiho Ryu Su Hyun Park Ju-Ock Kim Jang-Hee Hong Jeong Ho Seok Choong Jae Lee

BACKGROUND We investigated whether wogonin and apigenin significantly affect the epidermal growth factor receptor (EGFR) signaling pathway involved in MUC5AC mucin gene expression, and production from cultured airway epithelial cells; this was based on our previous report that apigenin and wogonin suppressed MUC5AC mucin gene expression and production from human airway epithelial cells. METHO...

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