BACKGROUND Oxaliplatin can induce peripheral neuropathy (OXIPN) as an adverse side effect in cancer patients. Until now, no effective preventive or therapeutic drug has been developed; therefore, the dose-limiting factor of OXIPN is still an obstacle in the use of oxaliplatin to treat cancer patients. In the present study, we report for the first time that the aqueous extract of Lithospermi rad...

The wall-to-lumen ratio (WLR) of the vasculature is a promising early marker of retinal microvascular changes. Recently, adaptive optics scanning laser ophthalmoscopy (AOSLO) enabled direct and noninvasive visualization of the arterial wall. Using AOSLO, we analyzed the correlation between age and WLR in 51 normal subjects. In addition, correlations between blood pressure and WLR were analyzed ...

Wall-to-lumen ratio of retinal arterioles might serve as an in vivo parameter of vascular damage. We analyzed the impact of brachial clinic blood pressure (BP), of central BP, and of 24-hour BP on wall-to-lumen ratio (WLR) of retinal arterioles. In 295 subjects (147 men; age range, 22-72 years; mean age, 54±7 years), WLR of retinal arterioles was assessed in vivo using scanning laser Doppler fl...

Introduction: Wark-Lovering rims (WLR) consist of a sequence of mono-mineral layers a few microme-ters thick (hibonite, perovskite, spinel, melilite, anor-thite, pyroxene, olivine) surrounding most coarse-grained Ca-Al-rich inclusions (CAIs) [1]. Despite numerous studies, their formation is still not well understood. Based on their mineralogy [1], their rare earth element (REE) content [2] or t...

The workload loss ratio (WLR) is a key quantity from the point of Quality of Service (QoS) provisioning in packet-based communication, hence it’s estimation is an important issue. The existing results in the area of WLR approximation usually interpret the workload loss as a product of some well assessable quantities. We call this approach as the indirect approximation of the WLR. The drawback o...

For the quantitative analysis of ligand-receptor dynamic positron emission tomography (PET) studies, it is often desirable to apply reference tissue methods that eliminate the need for arterial blood sampling. A common technique is to apply a simplified reference tissue model (SRTM). Applications of this method are generally based on an analytical solution of the SRTM equation with parameters e...

The coherent frequency (CF) of the auditory evoked response (AER) is derived using auditory clicks presented at frequencies in the range 5-47 Hz. CF and psychological performance were measured while seven subjects breathed isoflurane in doses increasing from 0% to 0.2%, 0.4% and 0.8% end-tidal concentration and then decreasing to 0%. With increasing doses of isoflurane, CF decreased and there w...

The effects of axial stellar rotation on the wind–momentum relation (WLR) for determining the extragalactic distances are investigated. Despite the fact that the mass loss rates grow quite a lot with rotation, remarkably the effects on the WLR are found to be very small on the average. As an example, for an average orientation angle between the rotation axis and the line of sight, the luminosit...

Background Patients with prediabetes are at risk for diabetes, cardiovascular events, and microvascular complications. The rtx1 (Imagine Eyes, France) permits early detection of changes in the retinal photoreceptors and vessels. Objective Cone parameters and retinal microvasculature were analyzed with the rtx1 in 12 prediabetic patients and 22 healthy subjects. The analysis was based on cone ...

The Balmer lines of four A Ia-supergiants (spectral type A0 to A3) and fourteen B Ia and Ib-supergiants (spectral type B0 to B3) in the solar neighbourhood are analyzed by means of NLTE unified model atmospheres to determine the properties of their stellar winds, in particular their wind momenta. As in previous work for O-stars (Puls et al. 1996) a tight relationship between stellar wind moment...