We consider the Whitehead problem for principal ideal domains of large size. It is proved, in ZFC, that some p.i.d.’s of size ≥ א2 have nonfree Whitehead modules even though they are not complete discrete valuation rings. A module M is a Whitehead module if ExtR(M,R) = 0. The second author proved that the problem of whether every Whitehead Z-module is free is independent of ZFC + GCH (cf. [5], ...