how to cite this article: shakiba m, nejad biglari h, alaee mr. digital and dental malformation and short stature in a patient with neurological problems: a variant of the oculodentodigital dysplasia syndrome or a new syndrome?iran j child neurol autumn 2012; 6(4): 51-54.   abstract several syndromes have been recognized with digital abnormality and cns involvement such as oculodentodigital dys...

background: the purpose of this study is to investigate the relationship between the cognitive impairment and naa/cr and cho/cr ratios in the proton magnetic resonance spectroscopy (1hmrs), and to assess the importance of 1hmrs in the early diagnosis of cognitive impairment in patients with ischemic white matter lesions (wmls). materials and methods: a total of 45 patients (23males and 22 femal...

OBJECTIVE White matter lesions are often seen on MR scans of elderly non-demented and demented people. They are attributed to degenerative changes of small vessels and are implicated in the pathogenesis of cognitive decline and dementia. There is evidence that especially periventricular white matter lesions are related to cognitive decline, whereas subcortical white matter lesions may be relate...

white matter lesions (wmls) are commonly observed in strokepatients with small vessel disease (svd) and are thought toresult from a progressive, irreversible disease process followingarteriolosclerosis. in this study, we report a case of partialdisappearance of wmls 1 year after a lacunar stroke in a69-year-old man with evidence of svd. we also discuss possiblemechanisms associated with this ob...

CONTEXT The role of macrostructural white matter changes, such as atrophy and white matter lesions, in cognitive decline is increasingly being recognized. However, in the elderly population, these macrostructural changes do not account for all variability in cognition. Measures reflecting white matter microstructural integrity may provide additional information to investigate the relation betwe...

Introduction: Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS), affecting mostly young people at a mean age of 30 years. Magnetic resonance imaging (MRI) is one of the most specific and sensitive methods in diagnosing and detecting the evolution of multiple sclerosis disease. But it does not have the ability to differentiate between distinct histopathologic...

MicroRNA expression profiles of patients with multiple sclerosis (MS) have revealed differences from healthy controls both in cells from the peripheral circulation and in specimens from white matter lesions. Here, we studied differences in microRNA expression and in their predicted mRNA targets in white and grey matter lesions of patients with MS as compared with white and grey matter brain tis...

We report a case of methanol intoxication in which the initial CT scans appeared normal. MR at 4 days showed the typical putaminal lesions of methanol intoxication and, in addition, peripheral white matter lesions that spared a thin rim of subcortical white matter. A CT scan at 17 days showed the putaminal and white matter lesions. The white matter lesions correspond well to lesions previously ...