Size enlargement of fine powders by wet granulation involves mixing of fine particles with a binder liquid to form larger wet granules and drying them by evaporation of the binder liquid to form larger dry granules. Identification of the time for completion of granulation process is critical as further mixing of dry granules is providing extra energy for their attrition. In a batch fluidized be...

The objective of the present investigation was to design suitable Immediate release tablet formulation of Aceclofenac by using cross carmellose sodium as super-disintegrant in four different concentrations i.e., 0, 4, 6, 8% w/w of tablet weight by two granulation methods i.e., Wet and melt granulation methods. The objective of the research was to compare the two granulation methods i.e., wet an...

In the pharmaceutical industry, the three most common granulation processes for solid dosage form production are wet granulation, dry granulation (roller compaction) and direct blending. Yet, despite being well-established techniques, each has its drawbacks. Moisture-activated dry granulation (MADG) was developed in response to the difficulties experienced with wet granulation, in terms of endp...

Using furosemide (FU) as a model drug, we examined the wet granulation method as a way to improve the taste masking and physical characteristics of orally disintegrating tablets (ODTs). In the wet granulation method, yogurt powder (YO) was used as a corrective and maltitol (MA) was used as a binding agent. The taste masked FU tablets were prepared using the direct compression method. Microcryst...

The matrix tablets were prepared by using Eudragit L 100, Poly ethylene oxide and Carbopol 971 P. The granules of Zidovudine using above polymers were prepared by direct mixing, wet granulation with water and wet granulation with IPA. The granules were characterized for the morphological study, bulk density, tapped density and particle size distribution. The granules were compressed in to table...

Efavirenz, a widely prescribed anti retroviral drug belongs to class IΙ under BCS and exhibit low and variable oral bioavailability due to its poor aqueous solubility. Its oral absorption is dissolution rate limited and it requires enhancement in the solubility and dissolution rate for increasing its oral bioavailability. The objective of the study is to evaluate the feasibility of formulating ...

Granulation, the process of particle enlargement by agglomeration technique, is one of the most significant unit operations in the production of pharmaceutical dosage forms, mostly tablets and capsules. Granulation process transforms fine powders into free-flowing, dust-free granules that are easy to compress. Nevertheless, granulation poses numerous challenges due to high quality requirement o...

To generate products containing a stable form of clarithromycin (CAM) (form II) regardless of the initial crystal form of CAM or type of granulation solvent, the effects of five surfactants, or a water-soluble polymer (macrogol 400) were determined on the crystal transition of CAM. The metastable form (form I) was kneaded with water, after adding surfactants, or a water-soluble polymer. Form II...

Purpose: To determine excipient and ibuprofen:excipient mixture sensitivity to reprocessing produced by either direct compression or wet granulation. Methods: The effect of excipient type, technology and reprocessing on flow, compressibility and compactibility was assessed using and 8x2x2 factorial design. Design Expert® v.8.01 software was employed for data analysis. Pure excipients were proce...

Jørgensen, A.C., 2004. Increasing process understanding of wet granulation by spectroscopic methods and dimension reduction tools Dissertationes Biocentri Viikki Universitatis Helsingiensis, 20/2004, 62 pp. ISBN 952-10-1955-7 ISBN 952-10-1956-5 (pdf) ISSN 1239-9469 Wet granulation is a common unit operation applied in the pharmaceutical industry. It is a complex process where several interrelat...