obesity is one of the health threatening problems and the second preventable mortality factor, the prevalence of which is increasing. the economic burden of obesity is estimated at 2-7% of the total healthcare costs and it is predicted to be top health problem of the world in 2025. therefore, following up obesity and developing effective clinical interventions is a significant measure taken in ...

Obesity is a world-wide pandemic and its incidence is on the rise along with associated comorbidities. Currently, there are few effective therapies to combat obesity. The use of lifestyle modification therapy, namely, improvements in diet and exercise, is preferable over bariatric surgery or pharmacotherapy due to surgical risks and issues with drug efficacy and safety. Although they are initia...

BACKGROUND Older adults are less able to conserve lean mass relative to fat mass with weight change. A cycle of weight loss and regain in an older individual could accelerate sarcopenia. We examined whether older adults experiencing weight loss and regain would show a greater loss of lean mass during a weight-loss period than gain in lean mass during the weight-regain period, thus have overall ...

BACKGROUND Despite initial successful weight loss, some patients may experience weight regain following Roux-en-Y gastric bypass (RYGB). OBJECTIVE To assess the impact of weight regain on bariatric patients' quality of life (QoL). METHODS This was a prospective cross-sectional study. Fifty-six consecutive RYGB patients were recruited and divided into weight-regain and weight-stable cohorts....

OBJECTIVES We sought to determine: (1) if early weight regain between 1 and 2 years after Roux-en-Y gastric bypass (RYGB) is associated with worsened hepatic and peripheral insulin sensitivity, and (2) if preoperative levels of ghrelin and leptin are associated with early weight regain after RYGB. METHODS Hepatic and peripheral insulin sensitivity and ghrelin and leptin plasma levels were ass...

Dietary restriction interventions are effective for weight loss and reduction of chronic disease risk. Unfortunately, most people tend to regain much of this lost weight within one year after intervention. While some studies suggest that minor degrees of weight regain have no effect on metabolic disease risk parameters, other studies demonstrate a complete reversal in metabolic benefits. In lig...