BACKGROUND Specialist Lifestyle Management (SLiM) is a structured patient education and self-management group weight management programme. Each session is run monthly over a 6-month period providing a less intensive long-term approach. The groups are patient-centred incorporating educational, motivational, behavioural and cognitive elements. The theoretical background, programme structure and p...

A new class of recently discovered antineoplastic agents, the pyridyl cyanoguanidines, exert a potent antitumor activity in rodents after oral administration. Optimization in vitro and in vivo has resulted in the selection of the lead candidate CHS 828 (N-(6-chlorophenoxyhexyl)-N'cyano-N"-4-pyridylguanidine). CHS 828 was found to exert potent cytotoxic effects in human breast and lung cancer ce...

IMPORTANCE Many claims have been made regarding the superiority of one diet or another for inducing weight loss. Which diet is best remains unclear. OBJECTIVE To determine weight loss outcomes for popular diets based on diet class (macronutrient composition) and named diet. DATA SOURCES Search of 6 electronic databases: AMED, CDSR, CENTRAL, CINAHL, EMBASE, and MEDLINE from inception of each...

BACKGROUND Limited evidence exists about the role of education and own educational mobility on body weight trajectory. A better understanding of how education influences long term weight gain can help us to design more effective health policies. METHODS Using random effects models, the association between i) highest education (n = 10 018) and ii) educational mobility over a 9 year period (n =...

BACKGROUND To our knowledge, research has not been conducted on bicycle riding and weight control in comparison with walking. Our objective was to assess the association between bicycle riding and weight control in premenopausal women. METHODS This was a 16-year follow-up study of 18,414 women in the Nurses' Health Study II. Weight change between 1989 and 2005 was the primary outcome, and the...

BACKGROUND Obesity is closely related to type 2 diabetes mellitus, and weight reduction is an important part of the care delivered to obese persons with diabetes. The objective of this review was to assess the efficacy of pharmacotherapy for weight loss in adults with type 2 diabetes. METHODS A systematic review of the literature was performed, and studies were included if pharmacotherapy was...

AIMS To determine the effects of glucagon-like peptide-1 receptor agonists compared with placebo and other anti-diabetic agents on weight loss in overweight or obese patients with type 2 diabetes mellitus. METHODS Electronic searches were conducted for randomised controlled trials that compared a glucagon-like peptide-1 receptor agonist therapy at a clinically relevant dose with a comparator ...

OBJECTIVES To determine the effectiveness of a weight-management program with personal counseling by phone or e-mail. METHODS A randomized controlled trial of a 6-month program comparing two modes of intervention delivery (phone, n = 462; Internet, n = 464) with self-directed materials (control, n = 460), among overweight employees. Change in body weight after 2 years was the main outcome. ...

BACKGROUND Studies have suggested that moderately high protein diets may be more appropriate than conventional low-fat high carbohydrate diets for individuals at risk of developing the metabolic syndrome and type 2 diabetes. However in most such studies sources of dietary carbohydrate may not have been appropriate and protein intakes may have been excessively high. Thus, in a proof-of-concept s...