An efficient synthesis of isoquinoline-2,3-dicarboxylates is described via one-pot reactions of isoquinoline and alkyl bromids with dialkyl acetylenedicarboxylates in water at 70oC. The mild reaction conditions and high yields of the products exhibit the good synthetic advantage of these methods. 

cui nanoparticles as an expedient and recyclable catalyst for the synthesis of n-cyclohexyl-3-aryl-quinoxaline-2-amines in ethanol via a multi-component reaction are established. the products were separated from the catalyst simply by filtration. the catalyst could be recycled and reused for several times without noticeably decreasing the catalytic activity.

ABSTRACT Knoevenagel condensation of barbituric acids with aromatic aldehydes containing one or two formyl groups was carried out. 5-Arylidenebarbituric acids underwent smooth hetero-Diels-Alder (HDA) reactions with enol ethers to afford cis and trans diastereoisomers of pyrano[2,3-d]pyrimidine-2,4-diones and 5,5'-(1,4-phenylene)bis[2H-pyrano[2,3-d]pyrimidine-2,4(3H)-dione] derivatives in excel...

An efficient method to synthesis the 2H-pyrans using three component reactions of dithiocarbamats, activated acetylenes and isocyanides in water as the solvent is described. In these reactions, synthesis of 2H-pyrans is possible based on the one-pot reaction and without using any catalyst. The mild reaction conditions and high yields of the products exhibit synthetic advantage of these methods.

Pd nanoparticles generated in green reaction media (viz. ionic liquids and water) catalyze the one-pot sequential Heck and Suzuki coupling reactions of bromo-chloroarenes to afford unsymmetrically substituted arenes in good yields.

A water-soluble squaric acid dialkyl diester derivative is presented, which enables one-pot, two-step amine-selective protein conjugation reactions with (functional) amines in water. This reagent not only allows all-aqueous protein modifications, but also tolerates e.g. hydroxyl groups and can also be used for the modification of proteins with water-insoluble amines.

A variety of aldehydes reacted with iodine in ammonia water at room temperature to give the nitrile intermediates, which were trapped by addition of hydrogen peroxide, sodium azide, or dicyandiamide to produce their corresponding amides, tetrazoles, and 1,3,5-triazines in modest to high yields. The one-pot tandem reactions were conducted in water media, and the products were obtained simply by ...