We examined whether non-enzymatic antioxidant defense systems are disrupted in the brain of rats with water-immersion restraint stress. When rats were exposed to water-immersion restraint stress for 1.5, 3 or 6 h, the brain had decreased ascorbic acid and reduced glutathione contents and increased lipid peroxide and nitric oxide metabolites contents at 3 h and showed further changes in these co...

conclusions our results showed that mo extract may have a gastroprotective effect against experimental gastric ulcers in rats. the exact mechanism has not yet been determined, but it may be due to enhancing enzymatic antioxidant defenses and inhibiting lipid peroxidation. materials and methods male wistar rats (200 - 250 g) were starved for 24 hours prior to the induction of gastric ulceration ...

introduction: alhagi camelorum belongs to the leguminosae family is used in iranian folk medicine to treat some gastric diseases. the present study was undertaken to evaluate the alhagi camelorum aqueous extract for anti-ulcer activity in rats. methods: male wistar rats were pretreated with the a. camelorum aqueous extract (150, 300 or 450 mg/kg of b.w., p.o.) before induction of gastric ulcer ...

Introduction: Alhagi camelorum belongs to the Leguminosae family is used in Iranian folk medicine to treat some gastric diseases. The present study was undertaken to evaluate the Alhagi camelorum aqueous extract for anti-ulcer activity in rats. Methods: Male Wistar rats were pretreated with the A. camelorum aqueous extract (150, 300 or 450 mg/kg of B.W., P.O.) before induction of gastric ul...

5-hydroxytryptamine (5-HT) is involved in the stress-induced alteration of colonic functions, specifically motility and secretion, but its precise mechanisms of regulation remain unclear. In the present study, we have investigated the effects of 5-HT on rat colonic mucosal secretion after acute water immersion restraint stress, as well as the underlying mechanism of this phenomenon, using short...

Eight genes showed significant changes in expression in mice under psychophysiological stress provided by cage-restraint and water-immersion. The transcription level of most of these genes was affected in all the tissues analyzed, and some of them were responsive genes in several different stress systems. Peculiarly, the expression level of one gene, cdc2-like kinase 1 (CLK1), was reduced only ...