ion channels are responsible for control of cell function in excitable tissues such as heart and brain and also in organs and tissues traditionally thought to be non- excitable including liver and epithelium. in the present research, the effect of lead (pb2+) on ca2+ -dependent action potential and currents was studied in f77 neuronal soma membrane of helix aspersa. for this purpose, action pot...

A novel ZVZCS isolated dual series-resonant active-clamp dc–dc converter is proposed to obtain high efficiency. The proposed converter employs an active-clamp technique, while a series-resonant scheme controls the output voltage with the complementary pulse width modulation controller. The active-clamp circuit serves to recycle the energy stored in the leakage inductance or the magnetizing ...

In this paper, a boost converter with a clamp circuit is proposed for high intensity discharge (HID) lamp application. The clamp circuit provides zero voltage turn on for both main and clamp switches. Compared to conventional boost converters, the proposed converter has the following advantages: (i) high voltage gain without suffering from extreme duty ratio, (ii) low stress on the switches and...

buthotus schach is one of the dangers scorpion in iran that belong to the buthidae family. toxins are existing in venom scorpion, modulate the ion channels by blocking or opening the pore of the channel or by altering the voltage gating and useful as pharmacological tools. in the present study, we investigated the effect of venom and its obtained fractions by gel filtrations on electrophysiolog...

Ion channels are responsible for control of cell function in excitable tissues such as heart and brain and also in organs and tissues traditionally thought to be non- excitable including liver and epithelium. In the present research, the effect of lead (Pb2+) on Ca2+ -dependent action potential and currents was studied in F77 neuronal soma membrane of Helix aspersa. For this purpose, action pot...

The voltage-clamp electrophysiology method is the gold standard for measuring the function of ion channels. In the past, this technique has had limited applicability in pharmaceutical drug discovery because of its low throughput, steep learning curve, and challenges in standardization of the experiments. Recently, new electrophysiology platforms have been developed, which are based on the use o...

Much of what we know about the properties of ion channels in cell membranes has come from experiments using voltage clamp. In general, the method allows ion flow across a cell membrane to be measured as electric current, whilst the membrane voltage is held under experimental control with a feedback amplifier. The method was first developed by Cole (1949) and Hodgkin et al. (1952) for use with t...

introduction: human embryonic stem cells (hescs) are pluripotent cells that can proliferate and differentiate to many cell types. their electrophysiological properties have not yet been chracterzed. in this study, the passive properties (such as resting membrane potential, input resistance and capacitance) and the contribution of delayed rectifier k+ channel currents to the membrane conductance...