we describe a patient with hypercalcemia associated with the injection of high doses vitamin d as supplement for a period of six months. a 76-year-old woman had been taking an intramuscular injection of vitamin d 300,000 iu every ten days for six months. she was hospitalized with symptoms of hypercalcemia: chronic constipation, unstable gait, a chronic generalized musculoskeletal pain and incre...

In 1999, Vieth indirectly asked the medical community to produce any evidence 10,000 units of vitamin D a day was toxic, saying, “Throughout my preparation of this review, I was amazed at the lack of evidence supporting statements about the toxicity of moderate doses of vitamin D”. He added, “If there is published evidence of toxicity in adults from an intake of 250ug (10,000 IU)/d, and that is...

1. What should be included in the differential diagnosis of hypercalcemia? Are the patient’s laboratory findings consistent with her reported use of vitamin supplements? 2. What role does vitamin D play in Ca2+ homeostasis? 3. Other than excess nutritional supplement use, what are additional causes of vitamin D toxicity? 4. What are the symptoms of vitamin D toxicity? How should vitamin D toxic...

The dose of vitamin D that some researchers recommend as optimally therapeutic exceeds that officially recognized as safe by a factor of two; it is therefore important to determine the precise mechanism by which excessive doses of vitamin D exert toxicity so that physicians and other health care practitioners may understand how to use optimally therapeutic doses of this vitamin without the risk...

Vitamin D toxicity also known as hypervitaminosis D was previously believed to be rare. But with an increase in vitamin D supplementation several cases have been reported in literature. Fat soluble vitamins like Vitamin D, due to their ability to accumulate in the body, have a higher potential for toxicity than water soluble vitamins. The main clinical consequence of vitamin D toxicity is hyper...