background: to evaluate vdr gene variation and its interaction with immune regulatory molecules in osteoporosis. methods: totally 205 pre and postmenopausal women were recruited in the study. after an overnight fast, peripheral blood was taken and centrifuged to sprat serum for measurement of serum parathyroid hormone, 25 hydroxyvitamin d, osteocal­cin and cross laps. the fok i polymorphism in ...

b a ckground:  the purpose of our study was to investigate the possible effect of  bsm i vitamin d receptor (vdr’s) polymorphism on changes of the inflammatory and oxidative stress (os) biomarkers in response to daily intake of vitamin d- fortified yogurt drink ( doogh ) in subjects with type 2 diabetes (t2d). m ethods : in a randomized controlled trial, 100 t2d subjects were allocated to two g...

background: osteoporosis, or porous bone, is a disease characterized by low bone mass density (bmd) and structural deterioration of bone tissue, leading to bone fragility and increased risk of hip, spine, and wrist fractures. there are numerous risk factors for osteoporosis. while many of these factors are non-genetic in nature, there is a definite genetic component responsible for this conditi...

There are many immune mediated disorders with the corroborated role of vitamin D or Vitamin D Receptor (VDR) gene polymorphisms in their pathogenesis, immunologic regulation, and disease characteristics. Therefore, in this review, we searched PubMed data base in regard to the role of VDR gene polymorphisms in common autoimmune disorders, emphasizing on dermatologic diseases.

Background & Aims: 1,25-dihydroxyvitamin D3 (1,25 (OH)2 D3), the biologically active form of vitamin D, exerts an immunosuppressive effect through binding to its specific nuclear receptor. The present case-control study was done to examine the possible association of BsmI polymorphism in vitamin D receptor gene (VDR gene) with severity of multiple sclerosis (MS). Methods: 267 Iranian patients w...

background: peroxisome proliferator activated receptor gamma (pparγ), a member of nuclear receptor superfamily, comprises two isoforms in mouse. these two isoforms are encoded by different mrnas, which are arisen by alternative promoter usage. there are two promoter regions upstream of pparγ gene. a 3 kb fragment, containing several transcription factor binding sites, acts as pparγ1 promoter re...

Background Polycystic ovary syndrome (PCOS) is the most common endocrine disorder. The roles of vitamin D in the regulation of metabolic modulations specifically involving insulin action and reproduction processing are introduced. In addition, obesity appears to be closely associated with severity of PCOS. The aim of this study was to evaluate the effect of BMI on vitamin D levels in follicular...