Dietary factors regulate immunological function, but the underlying mechanisms remain elusive. Here we show that vitamin B9 is a survival factor for regulatory T (Treg) cells expressing high levels of vitamin B9 receptor (folate receptor 4). In vitamin B9-reduced condition in vitro, Treg cells could be differentiated from naïve T cells but failed to survive. The impaired survival of Treg cells ...

abstract background and aims: vitamins are essential constituents of our diet that longley have been known to influence the immune system. vitamin d3 and b9 have received particular attention in recent years as these vitamins have been shown to have an unexpected and crucial effect on the immune response. 1, 25(oh)2d3 metabolizing enzymes and vitamin d receptor (vdr) are present in many cell ty...

In one carbon reaction, tetrahydrofolate works as cofactor for the synthesis of glycine, serine, methionine, purines and thymidylate. Folate or vitamin B9 is not synthesized in humans therefore plants are the main source of this essential vitamin. Deficiency of vitamin B9 may cause severe health consequences like birth defects, megaloblastic anemia, cardiovascular disorders, cancers, etc. To re...

This work focused on determining the micronutrient status of Crocus sativus L.stigmas with studying different correlations between physical-chemical compounds (moisture, minerals, ash, total phenolic content, carotenoids, zeaxanthin, vitamins and antioxidant activity). The mineral composition (Na, K, Ca, Mg, P, Fe, Cu, Mn, Zn, Mo B) was analyzed by ICP-OES (Inductively Coupled Plasma - Optical ...

Background and aims: Vitamins are essential constituents of our diet that Longley have been known to influence the immune system. Vitamin D3 and B9 have received particular attention in recent years as these vitamins have been shown to have an unexpected and crucial effect on the immune response. 1, 25(OH)2D3 metabolizing enzymes and vitamin D r...

In two groups of apparently healthy non-obese non-smoking women aged 2030 years – 79 vegetarians (39 lacto-ovo-vegetarians /plant food, dairy products, eggs/, 40 semi-vegetarians /as lacto-ovo-vegetarians with addition of white meat and fish consumption/) and 81 non-vegetarians (control group on traditional mixed diet) were analyzed the dietary questionnaires of foodfrequency and measured the b...

HORTSCIENCE VOL. 41(1) FEBRUARY 2006 annuum L.), pineapple [Ananas comosus (L.) Merrill], potato (Solanum tuberosum L.), spinach, strawberry (Fragaria ×ananassa Duch.), and tomato (Lycopersicum esculentum Mill.). Ascorbic acid is critical in maintaining a healthy immune system, reducing the severity of colds by preventing secondary viral or bacterial infections, protecting against damage by red...

Inspired by the multifunctionality of vitamin D-binding protein and the multiple transient-binding behavior of some intrinsically disordered proteins (IDPs), a polymeric platform is designed, prepared, and characterized for combined delivery of dermal protective and anticancer bioactive cargos on the basis of artificial single-chain nano-objects mimicking IDPs. For the first time ever, simultan...

Hydrogels, due to their unique potentials such as high-water content and hydrophilicity are interest for the controlled release of drug molecules. The present study aims to create a controlled-release system through the preparation and characterization of hydrogels based on pH-sensitive polymers such as poly (acrylic acid). Poly (acrylic acid), p(AA), hydrogel has been synthesized by radical po...

The antioxidant activities based on the free radical scavenging, reducing power, and bleaching inhibition were investigated for the three commonly used honeys in Malaysia, namely, tualang, gelam, and acacia honey. The antioxidant capacity of the honey samples was correlated with their biochemical constituents such as total phenol, total flavonoid content, and total water-soluble vitamins (vitam...