نتایج جستجو برای: viral inactivation of plasma products
تعداد نتایج: 21227279 فیلتر نتایج به سال:
human parvovirus b19, the causative agent of fifth disease in childhood, is non-enveloped dna virus and resistant to many physicochemical agents. b19 is a potential risk to hemophiliac patients receiving blood products. to determine the prevalence of the corresponding antibody in patients with hemophilia a or b or von will brand’s disease (vwbd), we tested 180 hemophilia patients aged 1-45 year...
One of the main sources of a wide range of biological products as starting material is the human blood. These biological human plasma derived medicines play essential role in prevention and treatment of a variety of life threatening diseases. Mention to the starting material of these medicines which is blood or in another word human plasma, possibility of contamination by blood borne viruses ca...
Background and Aims: Fresh Frozen Plasma (FFP) is one of blood components. The risk of transmission of viruses from blood components regardless selection of blood donors and screening donated blood still remains. There are several methods for viral inactivation. In this study methylene blue (MB) photo inactivation process was used for inactivating viruses. Materials and Methods: In this study M...
the risks of transmitting viral infection by blood and plasma-derived products have long been known and still remain an area of concern. in this study, in the process of purifying human factor vii from prothrombin complex, sid treatment using tri-n-butyl phosphate and tween 80 was employed and its capability and efficacy was studied. the results indicated that the process did not affect the bio...
The risks of transmitting viral infection by blood and plasma-derived products have long been known and still remain an area of concern. In this study, in the process of purifying human factor VII from prothrombin complex, SID treatment using tri-n-butyl phosphate and Tween 80 was employed and its capability and efficacy was studied. The results indicated that the process did not affect th...
BACKGROUND In 2016 the World Health Organization declared the mosquito-borne Zika virus (ZIKV) a "public health emergency of international concern." ZIKV is a blood-borne pathogen, which therefore causes concerns regarding the safety of human plasma-derived products due to potential contamination of the blood supply. This study investigated the effectiveness of viral inactivation steps used dur...
Risk of transmission of hepatitis C virus (HCV) by clinical plasma remains high in countries with a high prevalence of hepatitis C, justifying the implementation of viral inactivation treatments. In this study, we assessed the extent of inactivation of HCV during minipool solvent/detergent (SD; 1% TnBP / 1% Triton X-45) treatment of human plasma. Luciferase-tagged infectious cell culture-derive...
BACKGROUND Parvovirus B19 (B19V) is a small, nonenveloped virus that typically causes a benign flu-like illness that occurs most frequently in childhood. The virus is resistant to current viral inactivation steps used in the manufacture of antihemophilic factor concentrates and B19V transmission through these products has been documented. Since 2000, B19V nucleic acid test (NAT) screening of pl...
background and objective: there is a concern on safety of human fresh frozen plasma (ffp) as it is a source of some medicinal products. the possibility of transmission of blood-borne are reported often due to emerging viruses. there are some pathogen reduction technologies (prt) to inactivate viruses. methylene blue (mb) based method is one of them. the aim of this study was to examine new desi...
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