vinca minor, vinca major, vinca variegata and vinca rosea are different species of vinca genus, of apocynaceae family. in addition to ornamental applications, they are placed in the group of medicinal plants , because of the various alkaloids they possess. the purpose of this research was the investigation of the antileishmanial effects of the methanolic and crude extracts of leaves and stems o...

Some hybrids of vinca alkaloids and phomopsin A, linked by a glycine pattern, have been synthesized in one or two steps, by an insertion reaction and shown to inhibit microtubule assembly. These compounds have been elaborated in order to interact with both the "vinca site" and the "peptide site" of the vinca domain in tubulin. Two out of three hybrids are potent inhibitors of microtubules assem...

Antimicrotubule Vinca alkaloids, such as vinblastine and vincristine, interfere with the dynamics of microtubules and have shown significant cell killing activity in a variety of tumor cells through induction of apoptosis. The mechanism by which Vinca alkaloids induce apoptosis is not entirely clear. In this study, we found that glucocorticoids inhibit Vinca alkaloid-induced apoptosis without a...

Vinca alkaloids are a subset of drugs obtained from the Madagascar periwinkle plant. They are naturally extracted from the pink periwinkle plant, Catharanthus roseus G. Don and have a hypoglycemic as well as cytotoxic effects. They have been used to treat diabetes, high blood pressure and have been used as disinfectants. The vinca alkaloids are also important for being cancer fighters. There ar...

Developing new methods for chemotherapy drug delivery has become a topic of great concern. Vinca alkaloids are among the most widely used chemotherapy reagents for tumor therapy; however, their side effects are particularly problematic for many medical doctors. To reduce the toxicity and enhance the therapeutic efficiency of vinca alkaloids, many researchers have developed strategies such as us...

Cancer is deadliest disease ever known. Vinca extract has the potential and beneficial in treating various cancer conditions. However, till date no known syrup of plant or its been formulated. a debilitated condition formulation evaluation herbal alcoholic vinca may serve patient compliance ease administration by oral route. The was formulated using Vinca. Syrups are easy to formulate help over...

vinca major, minor and rosea are three species of vinca genus and apocynaceae family. the present work is to investigate antimicrobial effects of these plants against candida albicans, pseudomonas aeroginosa and staphylococus aureus. alkaloids from leaf extracts had a better effect on pseudomonas aeroginosa than alkoloids from stem and root. alkaloids from stem extracts were more effective than...

A comparative study of the loading and retention properties of three structurally very closely related vinca alkaloids (vincristine, vinorelbine and vinblastine) in liposomal formulations has been performed. All three vinca alkaloids showed high levels of encapsulation when accumulated into egg sphingomyelin/cholesterol vesicles in response to a transmembrane pH gradient generated by the use of...

We have used a structure-activity approach to investigate whether the Vinca alkaloids inhibit cell proliferation primarily by means of their effects on mitotic spindle microtubules or by another mechanism or by a combination of mechanisms. Five Vinca alkaloids were used to investigate the relationship in HeLa cells between inhibition of cell proliferation and blockage of mitosis, alteration of ...