نتایج جستجو برای: vhs

تعداد نتایج: 670  

Journal: :Journal of virology 2003
Jenny A Murphy Rebecca J Duerst Tracy J Smith Lynda A Morrison

The herpes simplex virus (HSV) virion host shutoff (vhs) protein, the product of the UL41 (vhs) gene, is an important determinant of HSV virulence. vhs has been implicated in HSV interference with host antiviral immune responses, down-regulating expression of major histocompatibility complex molecules to help HSV evade host adaptive immunity. The severe attenuation of vhs-deficient viruses in v...

Journal: :iranian journal of veterinary medicine 2010
علیرضا غدیری reza avizeh ghazaleh fazli

in order to assess the influence of breed on the vertebral heart scale (vhs) of dogs, the vhs was measured and compared in left to right (ll) and right to left lateral (rl) views. for all dogs (n=56), the mean vhs on the rl radiographs [9.7 vertebra (v)] was significantly larger than the mean vhs on the ll radiographs (9.6 v) (p=0.047). doberman dogs had higher mean values of the vhs in ll (9.9...

Journal: :Journal of veterinary internal medicine 2011
P F Lord K Hansson C Carnabuci C Kvart J Häggström

BACKGROUND In canine mitral regurgitation (MR) the rate of heart enlargement increases in the last year before congestive heart failure (CHF). Measurement of heart size and its rate of increase may be useful tests for CHF in MR. OBJECTIVES To determine the value of vertebral heart scale (VHS) and its rate of increase (∆VHS units/month) for diagnosing the presence and predicting the onset of C...

Journal: :Journal of virology 2000
B J Geiss T J Smith D A Leib L A Morrison

The virion host shutoff (vhs) protein encoded by herpes simplex virus type 1 (HSV-1) destabilizes both viral and host mRNAs. An HSV-1 strain with a mutation in vhs is attenuated in virulence and induces immune responses in mice that are protective against corneal infection with virulent HSV-1, but it has the capacity to establish latency. Similarly, a replication-incompetent HSV-1 strain with a...

2015
Ya-Fen Liu Pei-Yun Tsai Fong-Yuan Lin Kuan-Hsun Lin Tien-Jye Chang Hui-Wen Lin Songkhla Chulakasian Wei-Li Hsu

Pseudorabies virus (PrV) belongs to the α-herpesvirinae of which human simplex virus (HSV) is the prototype virus. One of the hallmarks of HSV infection is shutoff of protein synthesis that is mediated by various viral proteins including vhs (virion host shutoff), which is encoded by the UL41 gene. However, the function of PrV vhs is poorly understood. Due to the low sequence similarity (39.3%)...

Journal: :Journal of virology 2002
David N Everly Pinghui Feng I Saira Mian G Sullivan Read

During lytic infections, the virion host shutoff (Vhs) protein (UL41) of herpes simplex virus destabilizes both host and viral mRNAs. By accelerating the decay of all mRNAs, it helps redirect the cell from host to viral gene expression and facilitates the sequential expression of different classes of viral genes. While it is clear that Vhs induces mRNA degradation, it is uncertain whether it is...

Journal: :Journal of virology 2001
P Lu F E Jones H A Saffran J R Smiley

The virion host shutoff protein (vhs) of herpes simplex virus (HSV) triggers global shutoff of host protein synthesis and accelerated mRNA turnover during virus infection and induces endoribonucleolytic cleavage of exogenous RNA substrates when it is produced in a rabbit reticulocyte (RRL) in vitro translation system. Although vhs induces RNA turnover in the absence of other HSV gene products, ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2007
Brunella Taddeo Maria Teresa Sciortino Weiran Zhang Bernard Roizman

The virion host shutoff (vhs) protein encoded by the U(L)41 gene of herpes simplex virus 1 is an endoribonuclease. The enzyme is introduced into the cell during unpackaging of the virion upon entry and selectively degrades mRNA for several hours. The RNase activity ceases after the onset of synthesis of late (gamma) viral proteins. Here we report that vhs protein does not accumulate in cells tr...

Journal: :Journal of virology 2010
Heidi G Page G Sullivan Read

The herpes simplex virus Vhs endonuclease degrades host and viral mRNAs. Isolated Vhs cuts any RNA at many sites. Yet, within cells, it targets mRNAs and cuts at preferred sites, including regions of translation initiation. Previous studies have shown that Vhs binds the translation factors eIF4A and eIF4H. Here, we show that Vhs binds the cap-binding complex eIF4F. Association with eIF4F correl...

Ghazaleh Fazli Reza Avizeh علیرضا غدیری,

In order to assess the influence of breed on the vertebral heart scale (VHS) of dogs, the VHS was measured and compared in left to right (LL) and right to left lateral (RL) views. For all dogs (n=56), the mean VHS on the RL radiographs [9.7 vertebra (v)] was significantly larger than the mean VHS on the LL radiographs (9.6 v) (p=0.047). Doberman dogs had higher mean values of the VHS in LL (9.9...

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