Objective(s): The aim of present study is to formulate mefenamic acid transdermal gel based on vesicular drug delivery approaches.Materials and Methods: For the preparation of mefenamic acid transdermal gel, transfersomes were selected as colloidal carriers. Transfersomes were prepared by hand shaking and thin film hydration techniques. The obtained transfersomes were characterized for vesicula...

Objective: The primary goal of this study was to develop a topical gel containing tramadol hydrochloride-loaded Niosomes injection technique as the vesicular carrier for site-specific delivery. Methods: niosomes were created by varying ratios nonionic surfactants (Tween 80, Tween 60, 20, Span and 80) cholesterol while keeping drug concentration constant. Results Discussion: Each formulation exa...

Lung cancer has the highest mortality rate as compared to other cancers. The anti-proliferative and antioxidant potential of epigallocatechin gallate (EGCG) Theaflavin -3,3’-digallate (TF3) can play a major role in treatment if delivered efficiently. To improve chemical stability medicinal EGCG TF3 respiratory tract, spanlastic is developed which composed Tween-80, Span-60, cholesterol encapsul...

hydatid disease is a common and major public health issue caused by parasite echinococcus granulosus . the highest prevalence of the parasite can be found in different parts of world like africa, australia, and south america. this infection can occurs in almost any part of the body. here we present clinical, radiological, histological features and treatment of a multi ve­sicular osseous hydatid...

Transdermal drug delivery system appears to be most promising delivery system due to their merits over conventional delivery systems. Recently, various strategies have been used to augment the transdermal delivery of bioactives. Mainly, they include iontophoresis, electrophoresis, sonophoresis, chemical permeation enhancers, microneedles, and vesicular system (liposomes, niosomes, elastic lipos...

this study aims to investigate the capability of forming itraconazole containing niosomes with span 60 and brij 58 as non-ionic surfactants. lower cost and higher stability makes niosomes a more suitable choice in comparison with liposomes.the capability to form vesicles as an itraconazole delivery system and the influence of different factors such as type of surfactant and molar ratio of chole...

Six patients with AIDS and AIDS related complex (ARC) who developed neuromuscular symptoms associated with vesicular changes in muscle fibres are reported. Two patients in the advanced stages of AIDS, who did not receive zidovudine, developed proximal limb weakness and wasting: both had a necrotising myopathy with an unusual segmental vesicular change of myofibres. There were numerous vesicles ...

Secretion of extracellular vesicles is a general cellular activity that spans the range from simple unicellular organisms (e.g. archaea; Gram-positive and Gram-negative bacteria) to complex multicellular ones, suggesting that this extracellular vesicle-mediated communication is evolutionarily conserved. Extracellular vesicles are spherical bilayered proteolipids with a mean diameter of 20-1,000...

Subcutaneous treatment of 50% EtOH extract of neem bark (Azadirachta indica A. juss) to male rats at the dose of 10 mg for 30 days caused arrest of spermatogenesis. The diameter of serminiferous tubule, Leydig cell nucleus and epithelial heights of epididymides were significantly reduced (p≤0.001). Sperm motility and density were significantly reduced. Reduced testicular and accessory organ pro...