background: angiogenesis is an important process in various physiologic and pathologic states. the most significant stimulator of angiogenesis is vascular endothelial growth factor (vegf). in contrast, vasohibin1 acts as an angiogenesis inhibitor which specifically inhibits new vessels formation. the aim of the present study was cloning and expression of vasohibin1 gene in e. coli as well as pu...

Vasohibin-1 is an intrinsic angiogenesis inhibitor, and is expressed in endothelial cells via induction by pro-angiogenesis factors. It is known to inhibit several processes of angiogenesis, with different mechanisms from extrinsic angiogenesis inhibitors. Vasohibin-2 is mainly expressed by mononuclear cells which have been mobilized from bone marrow. It not only promotes angiogenesis, but also...

We have recently shown that one allelic variant (rs3757441 CC versus TC/TT) of an EZH2 single nucleotide polymorphism (SNP) is significantly associated with shorter progression-free survival (PFS) and overall survival (OS) in metastatic colorectal cancer (mCRC) patients treated with first-line FOLFIRI plus bevacizumab [1]. EZH2 silences several tumor-suppressor genes, thereby enhancing cancer p...