نتایج جستجو برای: vardenafil

تعداد نتایج: 378  

2009
Tae-Soo Kim Il-Gyu Ko Yun-Hee Sung Sung-Eun Kim Bo-Kyun Kim Seung-Kook Park Mal-Soon Shin Chang-Ju Kim Sang-Jin Yoon Khae-Hawn Kim

This study was conducted to evaluate the effects of vardenafil (Levitra), a phosphodiesterase-5 (PDE-5) inhibitor, on cell proliferation in the hippocampal dentate gyrus and on 5-hyroxytryptamine (5-HT, serotonin) synthesis and tryptophan hydroxylase (TPH) expression in the rat dorsal raphe nucleus. Male Sprague-Dawley rats were divided into 6 groups (n=5 in each group): a control group, a 0.5 ...

Journal: :Drugs 1999
Gillian M Keating Lesley J Scott

UNLABELLED Vardenafil (Levitra) is a potent and highly selective oral phosphodiesterase type 5 (PDE5) inhibitor. Vardenafil improved erectile function in men with mild to severe erectile dysfunction (ED) of varying aetiology in two randomised, double-blind, multicentre, fixed-dose studies of 12 or 26 weeks' duration. Men receiving vardenafil 10 or 20 mg had significantly greater improvements in...

Journal: :Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2010
Suleyman Turk Yalcin Solak Seyfullah Kan Huseyin Atalay Mehmet Kilinc Erhan Agca Said Bodur

BACKGROUND Erectile dysfunction (ED) is prevalent in end-stage renal disease (ESRD) and has been associated with impaired health-related quality of life (HRQoL). HRQoL, in turn, is related to morbidity and mortality in ESRD patients. Previous studies have shown improved HRQoL with ED treatment using sildenafil and vardenafil. However, no study has examined the effects of sildenafil or vardenafi...

2011
Pei-Rong Ding Amit K. Tiwari Shinobu Ohnuma Jeferson W. K. K. Lee Xin An Chun-Ling Dai Qi-Si Lu Satyakam Singh Dong-Hua Yang Tanaji T. Talele Suresh V. Ambudkar Zhe-Sheng Chen

One of the major causes of chemotherapy failure in cancer treatment is multidrug resistance (MDR) which is mediated by the ABCB1/P-glycoprotein. Previously, through the use of an extensive screening process, we found that vardenafil, a phosphodiesterase 5 (PDE-5) inhibitor significantly reverses MDR in ABCB1 overexpressing cancer cells, and its efficacy was greater than that of tadalafil, anoth...

Journal: :Asian journal of andrology 2008
Hui Meng Tan Chong Min Chin Chong Beng Chua Edsal Gatchalian Apichat Kongkanand Clarence Lei Chang Moh Foo Cheong Ng Krisada Ratana-Olarn Dennis Serrano Akmal Taher Ismail Tambi Anupan Tantiwong Michael Wong Yuet Chen Wai-Chun Yip

AIM To evaluate the efficacy and tolerability of vardenafil, a phosphodiesterase type-5 (PDE-5) inhibitor, in men of Asian ethnicity with erectile dysfunction (ED). METHODS In this prospective, double-blind, multinational study, Asian men were randomized to receive vardenafil (10 mg) or placebo (4:1 ratio) for 12 weeks. The primary efficacy variables were the International Index of Erectile F...

Journal: :European urology 2008
Ling X De Young Trustin Domes Kokbin Lim Jeffery Carson Gerald B Brock

BACKGROUND Diabetic men generally have reduced efficacy with PDE-5 inhibitors (PDE5i) for the treatment of erectile dysfunction (ED). OBJECTIVE To determine whether chronic vardenafil exposure alters cavernous protein expression predicting improved erectile function in diabetes. DESIGN Forty-two adult male Sprague Dawley rats with streptozotocin-induced (50mg/kg IP) diabetes for 4 wk, were ...

2010
Mal Soon Shin Il Gyu Ko Yun Hee Sung Sung Eun Kim Bo Kyun Kim Chang Ju Kim Sang Won Lee Dong Hee Kim Joo Hyun Chang Khae Hawn Kim

PURPOSE Oxytocin is associated with the ability to form normal social attachments. c-Fos is an immediate early gene whose expression is used as a marker for stimulus-induced changes in neurons. The effect of phosphodiesterase-5 (PDE-5) inhibitors on oxytocin activation in the brain without sexual stimuli has not yet been reported. In the present study, we investigated the effects of vardenafil ...

2012
Edibe Karasu-Minareci Irem Hicran Ozbudak Gulay Ozbilim Gulay Sadan

Phosphodiesterase type-5 (PDE-5) inhibitors are novel and important options for the treatment of pulmonary arterial hypertension (PAH). Therefore, we aimed to examine effects of vardenafil, a PDE-5 inhibitor, on the pulmonary arteries isolated from rats with monocrotaline- (MCT-) induced pulmonary hypertension. MCT (60 mg/kg) or its vehicle was administered by a single intraperitoneal injection...

Journal: :Molecular pharmacology 2008
Huanchen Wang Mengchun Ye Howard Robinson Sharron H Francis Hengming Ke

Vardenafil has higher affinity to phosphodiesterase-5 (PDE5) than sildenafil and lower administered dosage for the treatment of erectile dysfunction. However, the molecular basis for these differences is puzzling because two drugs have similar chemical structures. Reported here is a crystal structure of the fully active and nonmutated PDE5A1 catalytic domain in complex with vardenafil. The stru...

Journal: :Journal of andrology 2002
Seong Choi Luke O'Connell Kweonsik Min Noel N Kim Ricardo Munarriz Irwin Goldstein Erwin Bischoff Abdulmaged M Traish

Vardenafil and sildenafil are potent and specific phosphodiesterase type 5 (PDE 5) inhibitors. In human penile cavernosal smooth muscle cells, we have previously shown that vardenafil has a lower biochemical inhibition constant (Ki) than sildenafil. In this study, we compared the efficacy of vardenafil and sildenafil in facilitating penile erection in a rabbit model. Penile erections were elici...

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