INTRODUCTION Vanadium compounds are insulin like drugs which are accompanied with nephrotoxicity and hepatotoxicity as their major side effects. Aerobic exercise is well known as an approach to reduce the side effects of many drugs. OBJECTIVES This study was designed to determine the role of aerobic exercise against vanadyl sulphate induced nephrotoxicity and hepatotoxicity in male rats. MA...

OBJECTIVE Vanadyl sulphate, an inorganic tetravalent salt of transition metal vanadium is conventionally used to treat diabetes and by athletes as body-building supplement. Vanadyl sulphate is a constituent of many supplements and herbal preparations available over the counter in many parts of the world. In this study the efficacy of the salt as hypoglycaemic agent and its effects on lipid prof...

vanadium salts have been suggested as a possible therapeutic agent for the treatment of diabetes. the aim of the present study was to clarify histological and immunohistochemical changes that occur in the pancreatic beta (β) cells of vanadyl sulphate (vs)-treated streptozotocin (stz) induced diabetic rats. male wi star rats were made diabetic by injecting a single intravenous dose of stz (40 mg...

Vanadyl ions (V0 2 + ) occur coordinated to other groups both in solids and liquids, bringing the total coordination to five or six. Usually the metal ion is surrounded by a distorted octahedron of oxygen ligands. However, the behaviour of the unpaired electron in the vanadyl complexes is dominated by the strong V = 0 bonding; as a result, most of the complexes possess very nearly a square pyra...

Numerous studies have focused on the growth regulation effect of vanadium compounds. In our preliminary investigation we have observed growth inhibition of rat hepatoma cell line H35-19 by inorganic vanadium salts. The aim of the present study was to determine the effect of vanadyl sulphate (VOSO4) on autocrine growth and survival of tumorogenic lung (A549) and prostate (DU145) human cell lines...

Background: There is not any in vivo studies that shows inducing of euglycemia by vanadyl is independent from plasma insulin.  Therefore in the present study we planned to investigate the antidiabetic effects of vanadyl in diabetic rats. Materials and Methods: Rats became severely diabetic by an IV injection of 50-55mg/kg streptozotocin (STZ), 15 days after the injection, the blood glucose of ...

The authors describe the influence of vanadyl sulphate on liver Golgi complexes in control and streptozotocin (STZ)-diabetic rats. VOSO4, one of inorganic vanadium compounds widely used in animal models and human diabetes, acts as an insulin-mimetic drug and is relatively well known as a complex activated or inhibited on many enzymes involved in carbohydrate or lipid metabolic pathways. A relat...

background: it is known that vanadyl compounds are capable of alleviating hyperglycemia in streptozotocin induced diabetic rats.   objective: to examine the effect of vanadyl sulphate (vs) on spermatogenesis of male rats.   methods: male rats (n=10) were administered 32 mg/kg/day of vs orally and 50 meq/l nacl (as drinking water) for one month.  meanwhile, 11 male rats, the control group, recei...

Background: It is known that vanadyl compounds are capable of alleviating hyperglycemia in streptozotocin induced diabetic rats. Objective: To examine the effect of vanadyl sulphate (VS) on spermatogenesis of male rats. Methods: Male rats (n=10) were administered 32 mg/kg/day of VS orally and 50 mEq/l NaCl (as drinking water) for one month.  Meanwhile, 11 male rats, the control group, received ...