conclusions evaluation of iranian traditional dosage forms like vaginal and rectal types could be an attractive topic of research and the current study can briefly represent the iranian traditional pharmaceutical knowledge on vaginal and rectal drug delivery. objectives the aim of this study is the investigation about iranian traditional pharmaceutical dosage forms of vaginal and rectal medicat...

There were many natural pharmaceutical dosage forms cited by Persian pharmacists and physicians in the historical pharmacopeias (Qarabadins). This work aimed to perform a comprehensive study on “Qarābādin-e-Sālehi” (1765 A.D.), one of the main Persian pharmaceutical manuscripts defining traditional dosage forms. All traditional dosage forms as well as their definitions, descri...

Microbicides are topically applied, user controlled dosage forms that are being developed to prevent the transmission of HIV during coitus. Early candidates focused on coitally dependent dosage forms such as gels and creams. More recent development has focused on broadening the coitally dependent options through the introduction of films and fast dissolving tablets. Additionally, it has become ...

Topical administration of clotrimazole represents the common use therapy in the antimycotic genitourinary tract treatment. Due to the fast self-cleaning action of the vagina, commercially available vaginal dosage forms with clotrimazole cannot assure prolonged contact time with mucosa, therefore the main objective of this study was to develop a dosage form for vaginal administration of clotrima...

Vaginitis is mostly caused by Trichomonas vaginalis leading to mild to severe infections in the vaginal mucosa. The treatment for this disease can be initiated with the help of antimicrobial and antifungal agents in various dosage forms. Novel dosage forms have gained prior significance in recent formulation researches due to their inevitable controlled drug release mechanism and site specific ...

The vagina, in addition to being a genital organ with functions related to conception, serves as a potential route for drug administration. Mainly used for local action in the cervico-vaginal region, it has the potential of delivering drugs for systemic effects and uterine targeting. Currently available vaginal dosage forms have several limitations, necessitating the need to develop novel drug ...

Infection with human immunodeficiency virus (HIV) remains a global public health concern and is particularly serious in low- and middle-income countries. Widespread sexual violence and poverty, among other factors, increase the risk of infection in women, while currently available prevention methods are outside the control of most. This has driven the study of vaginal microbicides to prevent se...

polarographic methods have been developed for the determination of two cephalosporins namely cefotaxime (ctx) and ceftriaxone (ctr) in pharmaceutical formulations. well defined peaks at potentials –1.432 v vs. sce for ctx and –1.627 v vs. sce for ctr were obtained in the presence of tungsten (vi). the method has been successfully applied for the determination of above mentioned cephalosporins i...

Vaginal dosage forms are seen as a viable option for empowering women to protect themselves from the risk of HIV transmission. Because of limited research in the field, there is a lack of suitable dissolution methods established for determination of drug release from vaginal formulations inside the vaginal tract. The main aim of this study was to develop a simple, reliable and reproducible in v...