نتایج جستجو برای: vaca c

تعداد نتایج: 1057856  

Journal: :Gastroenterology 2008
Daniela Basso Carlo-Federico Zambon Darren P Letley Alessia Stranges Alberto Marchet Joanne L Rhead Stefania Schiavon Graziella Guariso Marco Ceroti Donato Nitti Massimo Rugge Mario Plebani John C Atherton

BACKGROUND & AIMS The Helicobacter pylori gene cagA and s1 or m1 forms of vacA are more common in disease-associated strains. Recently, forms of cagA encoding multiple type C EPIYA segments (which increase phosphorylation-dependent CagA activity) and a new type i1 "intermediate region" polymorphism in vacA (which confers toxicity) have been described. We assessed the association of new and esta...

Journal: :Microbiology 2006
Darren P Letley Joanne L Rhead Keith Bishop John C Atherton

The Helicobacter pylori vacuolating cytotoxin VacA shares homology in its C-terminal domain with many autotransporter proteins, suggesting a similar mechanism of secretion. Like most autotransporters, VacA contains a single pair of cysteine residues located near the C-terminus of the passenger domain. This study aimed to investigate the role of these conserved cysteine residues. This involved c...

Journal: :Infection and immunity 2006
Victor J Torres Mark S McClain Timothy L Cover

The Helicobacter pylori VacA toxin is an 88-kDa secreted protein that causes multiple alterations in mammalian cells and is considered an important virulence factor in the pathogenesis of peptic ulcer disease and gastric cancer. We have shown previously that a VacA mutant protein lacking amino acids 6 to 27 (Delta6-27p88 VacA) is able to inhibit many activities of wild-type VacA in a dominant-n...

Journal: :Molecular microbiology 2000
M S McClain W Schraw V Ricci P Boquet T L Cover

Helicobacter pylori VacA is a secreted toxin that induces multiple structural and functional alterations in eukaryotic cells. Exposure of VacA to either acidic or alkaline pH ('activation') results in structural changes in the protein and a marked enhancement of its cell-vacuolating activity. However, the mechanism by which activation leads to increased cytotoxicity is not well understood. In t...

Journal: :Toxins 2016
Kinnosuke Yahiro Toshiya Hirayama Joel Moss Masatoshi Noda

Helicobacter pylori (H. pylori), a major cause of gastroduodenal diseases, produces VacA, a vacuolating cytotoxin associated with gastric inflammation and ulceration. The C-terminal domain of VacA plays a crucial role in receptor recognition on target cells. We have previously identified three proteins (i.e., RPTPα, RPTPβ, and LRP1) that serve as VacA receptors. These receptors contribute to th...

2009
Amanda Oldani Mireille Cormont Veronique Hofman Valentina Chiozzi Olivier Oregioni Alexandra Canonici Anna Sciullo Patrizia Sommi Alessia Fabbri Vittorio Ricci Patrice Boquet

Infection with Helicobacter pylori is responsible for gastritis and gastroduodenal ulcers but is also a high risk factor for the development of gastric adenocarcinoma and lymphoma. The most pathogenic H. pylori strains (i.e., the so-called type I strains) associate the CagA virulence protein with an active VacA cytotoxin but the rationale for this association is unknown. CagA, directly injected...

1998
Emanuele Papini Barbara Satin Nathalie Norais Marina de Bernard John L. Telford Rino Rappuoli

The effects of the vacuolating toxin (VacA) released by pathogenic strains of Helicobacter pylori on several polarized epithelial monolayers were investigated. Trans-epithelial electric resistance (TER) of monolayers formed by canine kidney MDCK I, human gut T84, and murine mammary gland epH4, was lowered by acid-activated VacA. Independent of the cell type and of the starting TER value, VacA r...

Journal: :PLoS Pathogens 2008
Vijay R. Gupta Hetal K. Patel Sean S. Kostolansky Roberto A. Ballivian Joseph Eichberg Steven R. Blanke

The vacuolating cytotoxin (VacA) of the gastric pathogen Helicobacter pylori binds and enters epithelial cells, ultimately resulting in cellular vacuolation. Several host factors have been reported to be important for VacA function, but none of these have been demonstrated to be essential for toxin binding to the plasma membrane. Thus, the identity of cell surface receptors critical for both to...

2013
Yuko Akazawa Hajime Isomoto Kayoko Matsushima Tsutomu Kanda Hitomi Minami Naoyuki Yamaghchi Naota Taura Ken Shiozawa Ken Ohnita Fuminao Takeshima Masayuki Nakano Joel Moss Toshiya Hirayama Kazuhiko Nakao

Vacuolating cytotoxin A (VacA) is one of the important virulence factors produced by H. pylori. VacA induces apoptotic cell death, which is potentiated by ammonia. VacA also causes cell death by mitochondrial damage, via signaling pathways that are not fully defined. Our aim was to determine whether endoplasmic reticulum (ER) stress is associated with VacA-induced mitochondrial dysfunction and ...

Journal: :international clinical neurosciences journal 0
seyedeh zahra bakhti department of biology, faculty of sciences, university of mohaghegh ardabili, ardabil, 56199-11367, iran saeid latifi-navid department of biology, faculty of sciences, university of mohaghegh ardabili, ardabil, 56199-11367, iran saber zahri department of biology, faculty of sciences, university of mohaghegh ardabili, ardabil, 56199-11367, iran abbas yazdanbod gastrointestinal cancer research center, ardabil university of medical sciences, ardabil, 56189-53141 iran

background: gastric cancer (gc) is the fifth common malignant disease and the third leading cause of cancer-related mortality in the world. ardabil, a northwestern province of iran, includes the highest rate of gc within the country. helicobacter pylori (h. pylori) vaca gene plays a major role in generating and maintaining the gastric inflammatory response , which alters the enteric nervous sys...

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