نتایج جستجو برای: v34l

تعداد نتایج: 25  

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2006
Marlies de Lange Toby Andrew Harold Snieder Dongliang Ge T Simon Futers Kristina Standeven Tim D Spector Peter J Grant Robert A S Ariëns

OBJECTIVE Activated factor XIII (FXIII) crosslinks fibrin to enhance the mechanical strength of a blood clot and increase its resistance to fibrinolysis. The prevalence of a common variant in the FXIII-A gene (V34L) has been reported to be lower in patients with myocardial infarction and ischemic stroke than in controls, suggesting a protective role for this polymorphism in vascular diseases. T...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2016
Cédric Duval Majid Ali Waleed W Chaudhry Victoria C Ridger Robert A S Ariëns Helen Philippou

OBJECTIVE Factor XIII (FXIII) cross-links fibrin upon activation by thrombin. Activation involves cleavage at residue 37 by thrombin, releasing an activation peptide. A common polymorphism (valine to leucine variant at residue 34, V34L), located in the activation peptide, has been associated with increased activation rates and paradoxically a protective effect in cardiovascular disease. There i...

Journal: :Stroke 2006
Rocio González-Conejero Israel Fernández-Cadenas Juan A Iniesta Joan Marti-Fabregas Victor Obach José Alvarez-Sabín Vicente Vicente Javier Corral Joan Montaner

BACKGROUND AND PURPOSE The identification of genetic and environmental factors that could improve the benefit/risk ratio of thrombolytic therapy in patients with ischemic stroke is crucial. METHODS We studied the role in the efficacy and side-adverse effects of thrombolytic therapy in stroke of 2 factors involved in the structure and stability of fibrin clot: fibrinogen levels and factor XIII...

Journal: :The Journal of biological chemistry 2000
T A Trumbo M C Maurer

In the blood coagulation cascade, thrombin cleaves fibrinopeptides A and B from fibrinogen revealing sites for fibrin polymerization that lead to insoluble clot formation. Factor XIII stabilizes this clot by catalyzing the formation of intermolecular cross-links in the fibrin network. Thrombin activates the Factor XIII a(2) dimer by cleaving the Factor XIII activation peptide segment at the Arg...

Journal: :Blood 2001
J Corral J A Iniesta R González-Conejero M Villalón V Vicente

Intracranial hemorrhage is the third most frequent cause of cerebrovascular disease, but few genetic risk factors have been associated with its development. Recently, it has been reported that some polymorphisms that affect clotting factors increase the risk for thrombosis. However, reports have analyzed the effect of polymorphisms influencing the hemostatic state in bleeding disorders insuffic...

2016
Bajram Kamberi Farije Kamberi Mirko Spiroski

BACKGROUND Acute first-ever ischemic stroke (FIS) is a heterogeneous, polygenic disorder. The contribution of vascular genetic variants as inherited causes of ischemic stroke has remained controversial. AIM To examine the association of genetic variants in vascular factors with the occurrence of FIS. MATERIAL AND METHODS The current research was performed in a group of 39 patients with FIS ...

2012
Vincenzo Pizza Anella Agresta Antonio Agresta Eros Lamaida Norman Lamaida Francesco Infante Anna Capasso

The relationship between genetic polymorphisms and migraine as a cause of an increased risk of thrombotic disorders development is still debated In this respect, factor V Leiden, factor V (H1299R), prothrombin G20210A, factor XIII (V34L), β-fibrinogen, MTHFR (C677T), MTHFR (A1298C), APO E, PAI-1, HPA-1 and ACE I/D seem to play a determinant role in vascular diseases related to migraine. The pre...

ژورنال: :مجله دانشگاه علوم پزشکی شهرکرد 0
بتول پورقیصری batoul pourgheysari shahrekord university of medical sciencesشهرکرد- رحمتیه- دانشگاه علوم پزشکی-دانشکده پزشکی- گروه پاتولوژی و هماتولوژی پژمان بشکار pezman beshkar shahrekord university of medical sciencesدانشگاه علوم پزشکی شهرکرد فاطمه آزادگان fatemeh azadegan shahrekord university of medical sciencesدانشگاه علوم پزشکی شهرکرد

زمینه و هدف: تعدادی از پلی مورفیسم­های ارثی فاکتور های انعقادی با پاتوژنز ترومبوآمبولی وریدی و سایر پیامد­های جانبی آن ارتباط دارد. با توجه به اینکه اطّلاعات محدودی از فراونی این پلی مورفیسم­ها در جمعیّت­های ایرانی در دست است، لذا این مطالعه با هدف بررسی دو مورد از پلی مورفیسم­های فاکتور 13 یعنی xiiia - v34l و xiiib-h95r در جمعیّت سالم انجام شد.   روش بررسی: در این مطالعه مقطعی 150 فرد سالم اهداکن...

Journal: :Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2008
Noora S Alakulppi Lauri E Kyllönen Jukka Partanen Kaija T Salmela Jarmo T Laine

BACKGROUND Acute rejection episodes and vascular complications are common after renal transplantation and have negative impact on the long-term patient and graft survival. We investigated whether the risks of acute rejection, thrombosis, infarction and graft loss could be predicted based on the presence of functional polymorphisms in the genes of the coagulation and endothelial inflammation cas...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید