In the eighteenth century, dramatic electrical performances were favourite entertainments for the upper classes, yet the therapeutic uses of electricity also reached the lower strata of society. This change in the social composition of electrical audiences attracted the attention of John Wesley, who became interested in the subject in the late 1740s. The paper analyses Wesley's involvement in t...

There is ample evidence that the use of safety behaviour can interfere with the progress of therapy, particularly if exposure is involved. As a result, it is widely asserted that safety behaviour is anti-therapeutic. However, an unqualified rejection of safety behaviour should be reconsidered because we now have theoretical justification, experimental evidence and clinical observations showing ...

Since the development of monoclonal antibodies twenty-five years ago, researchers and biotech companies have been looking to develop therapeutic uses for them. Michael Gross looks at some of the latest efforts.

This review highlights the pharmacology, pharmacokinetics, pharmacological actions, therapeutic uses and adverse effects of cannabinoids. The effect of cannabinoids on anaesthesia is mentioned briefly. Important advances have taken place in cannabinoid research over the last few years and have led to the discovery of novel ligands. The possible clinical applications of these ligands and the dir...

Clinical application of evidence-based pharmacogenomics information has the potential to help healthcare professionals provide safe and effective medication management to patients. However, there is a gap between the advances of pharmacogenomics discovery and the health professionals' knowledge regarding pharmacogenomics testing and therapeutic uses. Furthermore, pharmacogenomics education mate...

This historical review traces the con­ cept of work throughout the develop­ ment of occupational therapy. Para­ digm shifting is used as a framework for describing the conceptual defini­ tions and therapeutic uses of work in four developmental stages. T he concept of work is funda­ mental to our profession; the terms occupation and therapy con­ note the strong relationship be­ tween healing and...

T he field of neurotrophin biology has made great advances in recent years to include a greater understanding of signaling pathways and broader understanding of the diverse biological roles of these molecules. This review will focus primarily on the nerve growth factor family of neurotrophins and how recent descriptions of the molecular function of both the ligands and the receptors have helped...

number of new drugs which have appeared during the last three years have been included and the author has been very wise in exercising a judicious caution in their selection. The sulphanilamide group of drugs which, is still in an experimental stage has received adequate attention. The book has been well written and brings out with great clarity the really important actions and therapeutic uses...

Animal venoms have been used for therapeutic purposes since the dawn of recorded history. Only a small fraction, however, have been tested for pharmaceutical utility. Modern computational methods enable the systematic exploration of novel therapeutic uses for venom compounds. Unfortunately, there is currently no comprehensive resource describing the clinical effects of venoms to support this co...