prediction using pure standards is expected to be biased whenever the slope of the calibration is affected by the presence of sample matrix. moreover, in the presence of unknown spectral interferents, first-order algorithms like partial least squares cannot be used. in this study, a method for determination of carvedilol (car) in tablet and urine samples is proposed by excitation-emission fluor...

abstract background: in this study our purpose was to determine whether 8 and/or 12 hour urine total protein values correlate with the 24 hour value to confirm the diagnosis of pre-eclampsia. methods: the study population included 70 inpatients with hypertensive disorders of pregnancy. patient's urine was collected over 24 hours with the first 8 hours, next 4 hours, and remaining 12 hours in se...

a new method was developed for the spectral resolution by further determination of three- and  four-component  mixtures  of  drugs in urine samples through  the complementary application of multivariate curve resolution-alternating least squares with correlation  constraint. in the current study, a simple method was proposed to construct a calibration set for the mixture of drugs in the presenc...