Background: Uremic pruritus is one of the important problems in patients undergoing hemodialysis. Causing the mechanism of uremic pruritus in hemodialysis patients is complex and multifactorial. Almost 60 percent of hemodialysis patients suffer from uremic pruritus. Oral hydroxyzine is a common treatment for uremic pruritus of this patients. This study aimed to survey effect of hydroxyzine on u...

pruritus is a common and bothersome problem among uremic patients which negatively affects life quality and prognosis of the patient. various factors are known to be involved in the development of pruritus. the aim of this study was to assess the frequency and the factors which may have relationship with uremic pruritus, especially bone mineral metabolism indicators. current cross-sectional stu...

BACKGROUND Uremic pruritus is a common, but unpleasant, complication of end-stage renal disease. The uremic burden may differ between hemodialysis (HD) and peritoneal dialysis (PD) patients. This difference may also change the clinical characteristics of uremic pruritus between the 2 modalities. In this study, we investigated the uremic pruritus between patients on HD and PD. METHODS A total ...

Background and aim: Uremic pruritus is a relatively common and distressing problem for patients with chronic renal failure. Serotonin and histamine have been reported as possible mediators of uremic pruritus. Granisetron, a potent and selective inhibitor of 5-HT3 receptors was developed for relief of chemotherapy induced nausea. There are some studies about effect of Ondansetron in uremic...

Pruritus is a common problem in patients with chronic renal failure 25 to 35% before dialysis patients and 60 to 80% of dialysis patients may complain of pruritus (1). Despite advances in dialysis techniques and the treatment of uremic pruritus, it is remains an uncontrolled clinical problem in patients with chronic kidney disease (2). Results of a study have shown a 48% prevalence of pruritus ...

As one of the most troublesome complications in patients with chronic renal disease, the etiology of uremic pruritus remains unknown, and the current therapeutic approaches are limited and unsatisfactory. To identify potential biomarkers for improving diagnosis and treatment and obtain a better understanding of the pathogenesis of uremic pruritus, we compared serum metabolome profiles of severe...

background uremic pruritus is a common and bothersome complaint among end-stage renal disease which affect between 25% and 60% of this population .but there is no decisive cure for treatment of it. in this study, the effects of omega-3 for treatment of pruritus were investigated in hemodialysis patients. methods a double-blind randomized study was carried out in the form of placebo-controlled c...

BACKGROUND Renal itch is a relatively common and distressing problem for patients with chronic renal failure. Granisetron, is a potent and selective inhibitor of 5-HT3 receptors. There have been some studies about the effect of ondansetron in uremic pruritus and one case report has recently described relief of renal itch with granisetron. AIMS To evaluate the effect of Granisetron on uremic p...