نتایج جستجو برای: urd

تعداد نتایج: 157  

Journal: :Hong Kong medical journal = Xianggang yi xue za zhi 2009
H Huang X Y Lai

Unrelated donor (URD) is an acceptable source of stem cell grafts for adults. With the growth in available URD, improved human leukocyte antigen (HLA) typing technology and better understanding of HLA matching, the number of URD haematopoietic stem cell transplantation (URD-HSCT) is increasing dramatically in recent years. Peripheral blood stem cells have surpassed bone marrow as the preferred ...

Journal: :Blood 2002
Daniel J Weisdorf Claudio Anasetti Joseph H Antin Nancy A Kernan Craig Kollman David Snyder Effie Petersdorf Gene Nelson Philip McGlave

Allogeneic bone marrow transplantation (BMT) offers the only curative therapy for chronic myelogenous leukemia. We compared prospectively collected results of 2464 unrelated donor (URD) transplantations with 450 HLA-identical, matched sibling donor (MSD) transplantations performed at collaborating National Marrow Donor Program institutions. A total of 63% of URDs were matched at HLA-A, -B, and ...

Journal: :The Journal of biological chemistry 1984
J J Prior D V Santi

In acidic media, the 5,6-double bond of uridine is rapidly hydrated to give a small amount of 6-hydroxy-5,6-dihydrouridine (Urd-H2O), the mechanism of which is known from studies of the acid-catalyzed dehydration of Urd-H2O (Prior, J. J., Maley, J., and Santi, D. V. (1984) J. Biol. Chem. 258, 2422-2428). In addition to dehydration, Urd-H2O also undergoes direct hydrolysis of the N-glycosidic bo...

2017
Ji Eun Kim Jun Go Ji Eun Sung Hyun Ah Lee Woo Bin Yun Jin Tae Hong Dae Youn Hwang

BACKGROUND Uridine (Urd), which has been reported as a major component of RNA, plays an important role in various biological process including neuroprotection, biochemical modulation and glycolysis, although its role in constipation has yet to be established. Therefore, in this study, we investigated the laxative effects of Urd on chronic constipation. METHODS The constipation phenotypes and ...

2016
Wataru Tanaka Mitsuo Shoji Fumiaki Tomoike Yuzuru Ujiie Kyohei Hanaoka Ryuhei Harada Megumi Kayanuma Katsumasa Kamiya Toyokazu Ishida Ryoji Masui Seiki Kuramitsu Yasuteru Shigeta

A uridine-cytidine kinase (UCK) catalyzes the phosphorylation of uridine (Urd) and cytidine (Cyd) and plays a significant role in the pyrimidine-nucleotide salvage pathway. Unlike ordinary ones, UCK from Thermus thermophilus HB8 (ttCK) loses catalytic activity on Urd due to lack of a substrate binding ability and possesses an unusual amino acid, i.e. tyrosine 93 (Tyr93) at the binding site, whe...

2017
Jae-Ho Yoon Hee-Je Kim Sung-Soo Park Young-Woo Jeon Sung-Eun Lee Byung-Sik Cho Ki-Seong Eom Yoo-Jin Kim Seok Lee Chang-Ki Min Seok-Goo Cho Dong-Wook Kim Jong-Wook Lee Woo-Sung Min

Standard therapy for acute myeloid leukemia (AML) consists of hematopoietic cell transplantation (HCT) including autologous-HCT (AUTO) and allogeneic-HCT from a matched-sibling donor (MSD) or well-matched unrelated donor (WM-URD). When a conventional donor is not available, HCT from a partially-matched (PM)-URD or familial-mismatched donor (FMMD) is typically considered. We analyzed 561 patient...

2016
Marie T. Rubio Bipin N. Savani Myriam Labopin Emmanuelle Polge Dietger Niederwieser Arnold Ganser Rainer Schwerdtfeger Gerhard Ehninger Jürgen Finke Arnold Renate Charles Craddock Nicolaus Kröger Michael Hallek Pavel Jindra Mohamad Mohty Arnon Nagler

BACKGROUND Data comparing fully matched and mismatched-unrelated-donor (M- and mM-URD) allogeneic hematopoietic stem cell transplant (allo-SCT) following reduced intensity conditioning regimens for acute myeloid leukemia are limited. METHODS We retrospectively compared the outcome of 3398 patients above the age of 50 years who underwent 10/10 M-URD (n = 2567), 9/10 (n = 723), or 8/10 (n = 108...

Journal: :Cancer research 1987
J W Darnowski C Holdridge R E Handschumacher

A previous report from this laboratory indicated that the concentration of free uridine (Urd) in many normal murine tissues greatly exceeds that in plasma. We now report that Urd uptake by isolated murine splenocytes is concentrative, and that the rate of uptake from medium containing 10 to 500 microM [3H]Urd conforms to a process that is saturable with a Km of 38.0 +/- 4.1 (SE) microM and Vmax...

Journal: :Blood 1999
V K Prasad N A Kernan G Heller R J O'Reilly S Y Yang

High incidences of graft failure and graft-versus-host disease in the recipients of bone marrow transplantations (BMT) from unrelated donors (URD) may reflect the existence of allelic disparities between the patient and the URD despite apparent HLA identity at HLA-A, HLA-B, and HLA-DRB1 loci. To identify the extent and pattern of allelic disparities at HLA-A and HLA-B loci, 128 patients and 484...

Journal: :Molecular pharmacology 2005
Jing Zhang Kyla M Smith Tracey Tackaberry Frank Visser Morris J Robins Lars P C Nielsen Ireneusz Nowak Edward Karpinski Stephen A Baldwin James D Young Carol E Cass

Human concentrative nucleoside transporters 1, 2, and 3 (hCNT1, hCNT2, and hCNT3) exhibit different functional characteristics, and a better understanding of their permeant selectivities is critical for development of nucleoside analog drugs with optimal pharmacokinetic properties. In this study, the sensitivity of a high-throughput yeast expression system used previously for hCNT1 and hCNT3 wa...

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