this study was designed to develop a modified tbi weight drop model for induction of focal mild cerebral injury. a stereotaxic coupled weight drop device was designed. principle arm of device carries up to 500g weights which their force was conveyed to animal skull through a thin nail like metal tip. to determine the optimal configuration of the device to induce mild tbi, six different trials w...

Brain injuries can interrupt descending neural pathways that convey motor commands from the cortex to spinal motoneurons. Here, we demonstrate a unilateral injury of hindlimb sensorimotor rats with completely transected thoracic cord produces postural asymmetry contralateral flexion and asymmetric withdrawal reflexes within 3 hr, as well in gene expression patterns lumbar cord. The injury-induc...

formula one legend michael schumacher hit his head severely while skiing on december 29, 2013. he was operated on for brain decompression and left in a coma fighting for life. in such severe brain injury with cerebral contusion and hemorrhage following head trauma, refractory to medical therapy and with increasing cerebral oedema and intracranial pressure, critically low cerebral perfusion can ...

Pupillary dysfunction, a concerning finding in the neurologic examination of the patient with an acute traumatic brain injury often dictates the subsequent treatment paradigm. Patients were monitored closely with an infrared pupillometer, with NPi technology, for acute changes in pupillary function. NPi technology applies a scalar value to pupillary function. A retrospective chart review was pe...

objectives the aim of this study was to present the incidence and characteristics of repeated tbi (rtbi) in iranian patients. patients and methods during one year, all admitted tbi patients with prior tbi history were enrolled into the study. in each patient, data such as age, gender, past medical history, injury cause, anatomic site of injury, tbi severity, clinical findings and ct scan findin...

background traumatic brain injury (tbi) is a worldwide problem, especially in countries with high incidences of road traffic accidents such as iran. patients with a single occurrence of tbi have been shown to be at increased risk to future tbi. this study presents incidences and characteristics of repeated traumatic brain injury (rtbi) in iran. materials and methods during one year, all admitte...

Background & Aim: Post-traumatic subdural hygroma can be associated with subdural or epidural hematoma. It is usually silent with mild symptoms and often disappears spontaneously needing no treatment. In this study, we investigated the clinical characteristics of subdural hygroma in patients with traumatic brain injury. Methods & Materials/Patients: In a cross-sectional study, data o...

traumatic brain injury (tbi) is one the most common cause of disability between young adults. these people have been socially isolated during post-surgery traumatic brain injury. in this study we investigated the effect of social isolation on the structural deficits after tbi in the young rats. young rats were divided into control group with social interaction, sham group with social isolation ...

Complications after unilateral acquired brain injury (ABI) can affect various areas of expertise causing (depending on the location of the lesion) impairment in occupational performance. The aim of this study was to analyze and compare the concepts of occupational performance and functional independence, both before and after a multicomponent intervention including occupational therapy, in pers...

there are only a few, non-evidence based, neuroprotective strategies for treatment and prevention of brain injuries after closed head trauma. to establish new therapy strategies, a novel animal model is needed. the aim of our investigation was to link standardized small animal models and actual patient medical care. data of experimental small animal studies often cannot be transferred to cns in...