background: this study was designed to examine a unique and low dose use of intravenous enoxaparin in elective percutaneous coronary intervention (pci) that would be applicable to an unselected population regardless of age, weight, and renal function. there is limited experience in anticoagulation using intravenous low-molecular-weight heparin in pci. methods: a total of 100 consecutive patient...

Heparin-İnduced Thrombocytopenia (HIT) is a life-threatening complication that occurs in small percentage of exposed patients (e.g. unfractionated heparin, Low Molecular Weight Heparin [LMWH]) regardless dose and treatment management.

background deep venous thrombosis (dvt) is a major risk of morbidity and mortality in morbid obese patients underwent bariatric surgery. there are some controversies in different kind of prophylactic strategies for dvt in laparoscopic bariatric surgeries. unfractionated heparin (ufh) is an available and reversible anticoagulant used for dvt prophylaxis. objectives this study aimed to compare cl...

The pharmacologic characteristics of low-molecular-weight (LMW) heparins and unfractionated heparin are reviewed, and clinical trials comparing LMW heparins with unfractionated heparin for the initial treatment of deep-vein thrombosis (DVT) are described. LMW heparins are derived from native heparin and range in mass from 3000 to 8000 daltons. All LMW heparins contain the antithrombin III-speci...

heparin has an unpredictable pharmacokinetics and the responses of individuals may vary distinctly. therefore, different dosing nomograms have been proposed. the aim of this study was to compare two prevalent nomograms to adjust heparin doses in hospitalized patients with acute coronary syndrome.  one hundred and forty patients received heparin infusions based on one of two nomograms. group 1 r...

OBJECTIVES To investigate the relative benefits of unfractionated heparin, low molecular weight heparin(LMWH), fondaparinux, and bivalirudin as treatment options for patients with ST segment elevation myocardial infarction undergoing percutaneous coronary intervention (PCI). DESIGN Mixed treatment comparison and direct comparison meta-analysis of randomized trials in the era of stents and P2Y...

background deep venous thrombosis (dvt) is a major risk of morbidity and mortality in morbid obese patients underwent bariatric surgery. there are some controversies in different kind of prophylactic strategies for dvt in laparoscopic bariatric surgeries. unfractionated heparin (ufh) is an available and reversible anticoagulant used for dvt prophylaxis. objectives this study aimed to compare cl...

Standard-dose heparin protocol (SDP) is the standard anticoagulant of unfractionated (UFH) for maintenance hemodialysis. To alleviate side effect heparin, low-dose (LDP) has been proposed, however, studies were scarce and inconclusive.

BACKGROUND AND OBJECTIVES Unfractionated heparin and low molecular weight heparins exert their anticoagulant effect by mobilizing tissue factor pathway inhibitor (TFPI) from the vascular endothelium into the blood circulation. We compared the influence of unfractionated heparin and enoxaparin on the anticoagulant function of cultured human endothelial cells. DESIGN AND METHODS Monolayers of h...

Physicochemical and anticoagulant characteristics of 27 samples from recent batches of commercially produced unfractionated heparin have been determined as part of the process of establishment of the 5th International Standard Unfractionated Heparin. They have been compared with current heparin standards (European Pharmacopoeia, United States Pharmacopoeia, Chinese), with the 4th International ...