The impact activity cliffs have on drug discovery is double-edged. For instance, whereas medicinal chemists can take advantage of regions in chemical space rich in activity cliffs, QSAR practitioners need to escape from such regions. The influence of activity cliffs in medicinal chemistry applications is extensively documented. However, the 'dark side' of activity cliffs (i.e. their detrimental...

We use high-resolution digital elevation models (DEMs) from unmanned aerial vehicle (UAV) surveys to document the evolution of four ice cliffs on the debris-covered tongue of Lirung Glacier, Nepal, over one ablation season. Observations show that out of four cliffs, three different patterns of evolution emerge: (i) reclining cliffs that flatten during the ablation season; (ii) stable cliffs tha...

Recent evidence that water flowed down the faces of some Martian cliffs has created an interest in the scientific community to explore these cliffs more thoroughly, perhaps using robots. This paper presents a technique for autonomous exploration that considers multiple forms of information while exploring. The method is applied to the problem of autonomously exploring cliffs. The exploring robo...

The activity cliff concept has experienced increasing interest in medicinal chemistry and chemoinformatics. Activity cliffs have originally been defined as pairs of structurally similar compounds that are active against the same target but have a large difference in potency. Activity cliffs are relevant for structure-activity relationship (SAR) analysis and compound optimization because small c...

The analysis of structure-activity relationships (SARs) of small bioactive compounds is a central task in medicinal chemistry and pharmaceutical research. The study of SARs is in principle not limited to computational methods, however, as data sets rapidly grow in size, advanced computational approaches become indispensable for SAR analysis. Activity landscapes are one of the preferred and wide...

underwater acoustic wireless sensor network (uawsn) use acoustic signalsto transmit data. acoustic signals in underwater environment have high bit errorrate, long propagation delay and limited bandwidth. another constraint in uwasnis energy. due to these constraints, design of energy and bandwidth efficient andpropagation delay aware mac protocol is a great challenge in uwasn.underwater sensor ...

Despite a growing body of descriptive, theoretical and practical knowledge about Information Systems Development (ISD), large-scale information system development and implementation projects still fail in high numbers. The deeper causes of such failures are only partially understood. This study uses an action research approach in which prescriptions and recommendations drawn from research on an...

REFERENCES [1] S. Kay, Fundamentals of Statistical Signal Processing, Volume 1, Estimation Theory. Englewood Cliffs, NJ: Prentice Hall, 1993. [2] S. Kay, Fundamentals of Statistical Signal Processing, Volume 2, Detection Theory. Englewood Cliffs, NJ: Prentice Hall, 1998. [3] A. Leon-Garcia, Probability and Random Processes for Electrical Engineering, 2nd ed. Reading, MA: Addison-Wesley, 1994. [...

history of underwater diving dates back to antiquity. breath-hold technique in diving was known to the ancient nations. however, deep diving progressed only in the early decades of the 19 th century as the result of advancements in efficient underwater technologies which subsequently led to invention of sophisticated sets of scuba diving in the 20 th century. currently, diving is performed for ...