BACKGROUND/AIMS: Acute myeloid leukemia (AML) is a clinically challenging disease with high interpatient variability in response to chemotherapy. Despite continuing advances in treatment options, current 5-year survival rates for pediatric AML are suboptimal at ~60%. Variability in treatment response and survival outcomes are due in part to the heterogeneous nature of AML, with many genetic les...

LIST ALL AUTHORS and AFFILIATIONS – underline presenting author Sarah Tomkovich, Raad Gharaibeh, Kathryn Winglee, Josee Gauthier, Rachel C. Newsome, Ye Yang, Marcus Muehlbauer, Christine Dejea, Anthony A. Fodor, Cynthia Sears and Christian Jobin Department of Medicine, University of Florida, Gainesville, FL, USA. Department of Infectious Diseases and Pathology, University of Florida, Gainesvill...

BACKGROUND/AIMS: Chemotherapy regimens are often used to manage acute myeloid leukemia (AML); however, the majority of cases eventually relapse. Therefore, a deeper understanding of the mechanisms governing AML growth and relapse is necessary to develop effective therapies. Previously, we demonstrated a novel mechanism whereby AML-induced endothelial cell (EC) activation leads to subsequent leu...

In this paper we tackle the specific problem of handwritten underline removal. The presence of these underlines is very frequent even in rare books and its removal a desired goal of the National Libraries in their process of building digital libraries. Two different techniques are applied and compared. One is based on mathematical morphology and the other on a recent published technique for lin...