background: maggot therapy has recently attracted considerable attention as an emerging debridement technique for wound healing. this study aimed to review the safety, effectiveness and economic evaluations of maggot debridement therapy for wound healing.   methods: to retrieve the relevant evidences, the cochrane library (until september 2014) was searched by appropriate keywords, using free t...

Buruli ulcer is a chronic painless skin disease caused by Mycobacterium ulcerans. The local nerve damage induced by M. ulcerans invasion is similar to the nerve damage evoked by the injection of mycolactone in a Buruli ulcer mouse model. In order to elucidate the mechanism of this nerve damage, we tested and compared the cytotoxic effect of synthetic mycolactone A/B on cultured Schwann cells, f...

A previous study has demonstrated that locally administered growth factors such as epidermal growth factor, basic fibroblast growth factor and hepatocyte growth factor can accelerate healing of experimental gastric ulcers in rats. That study indicates that locally administered growth factors can exert potent biological effects resulting in enhanced gastric ulcers healing. However, the fate of i...

Vagus nerve may play a role in serum glucose modulation. The complicated peptic ulcer patients (with perforation or/and bleeding) who received surgical procedures with or without vagotomy provided 2 patient populations for studying the impact of vagus nerve integrity. We assessed the risk of developing type 2 diabetes in peptic ulcer patients without and with complications by surgical treatment...

We investigated the associations between the self-evaluated pain status and two pain biomarker candidates, nerve growth factor and S100A8/A9, in exudate from venous leg ulcer to finally develop an objective pain evaluation method. Patients with venous leg ulcer participated in this cross-sectional observational study conducted between April and October 2014 at two medical facilities. During rou...

The first detailed description of the morphology gastric ulcer was reported ~230 years ago, but mechanism has yet to be elucidated. Moreover, peptic ulcers, including duodenal and are currently considered an infectious disease caused by Helicobacter pylori, how infection leads ulceration remains elusive. To address these challenges, a recently published Complex Causal Relationship applied analy...

External neurolysis of the nerve at fibro-osseous tunnels has been proprosed to treat or prevent signs, symptoms, and complications in the lower extremity of diabetes patients with sensorimotor polyneuropathy. Nerve decompression is justified in the presence of symptomatic compressed nerves in the several fibro-osseous tunnels of the extremities, which are known to be frequent in diabetes. Quit...

Prolonged local anaesthesia in soft perioral tissues may sometimes lead to accidental lip biting small children forming a traumatic ulcer. Healing of such ulcers has been reported enhance with treatment using low level laser therapy (LLLT). This case report describe two cases due bite following inferior alveolar nerve block caused during post period that were treated by LLLT. It resulted better...

BACKGROUND We evaluate the role of nerve growth factor (NGF) eye drops to treat a herpetic corneal ulcer resistant to systemic and local acyclovir treatment in an HIV-positive patient. CASE PRESENTATION A 68 year old HIV-positive male presented with a herpetic corneal ulcer which was treated unsuccessfully with acyclovir. Acyclovir sensitivity of herpes simplex virus was tested with a dye upt...

The nerve growth factor (NGF) belongs to a family of neurotrophic factors called neurotrophins. It was discovered as a molecule that stimulates the survival and maturation of developing neurons in the peripheral nervous system and has later been shown to protect adult neurons in the degenerating mammalian brain. Basic and clinical studies have been undertaken to use NGF as a therapeutic agent a...