نتایج جستجو برای: tyrosinase inhibitor

تعداد نتایج: 214578  

Journal: :applied biotechnology reports 0
azadeh taherian department of biology, school of science and agriculture, payame noor university of tehran, tehran, iran alireza jahangiri department of medicinal chemistry, school of pharmacy, ahwaz jundishapur university of medical sciences, ahwaz, iran forogh namjoyan department of pharmacognosy, school of phar-macy, ahwaz jundishapur university of medical sciences, ahwaz, iran seyed reza hajhosseini department of biology, school of science and agriculture, payame noor university of tehran, tehran, iran

melanin pigment plays a critical role in camouflage and   protection against harmful effects of solar radiation. melanogenesis is under   complex regulatory control by multiple agents. tyrosinase is a   multifunctional, which catalyzes the first two steps in mammalian   melanogenesis. in this study, inhibitory effects of astragalus fasciculifolius   and astragalus gypsicolus on diphenolase acti...

Saeed Emami, Seyedeh Mahdieh Hashemi,

Tyrosinase is a key enzyme for melanin biosynthesis, catalyzing the oxidation of L-tyrosine to L-dopaquinone. The tyrosinase inhibition is an effective approach to control hyperpigmentation in human skin and enzymatic browning in fruits and vegetables. Kojic acid is a naturally-occurring tyrosinase inhibitor which has been clinically used to treat the hyperpigmentation of skin. However, kojic a...

Journal: :journal of reports in pharmaceutical sciences 0
shabnam maghsoudi medical biology research center, kermanshah university of medical sciences, kermanshah, iran hadi adibi novel drug delivery research center, faculty of pharmacy, kermanshah university of medical sciences, kermanshah, iran marzieh hamzeh novel drug delivery research center, faculty of pharmacy, kermanshah university of medical sciences, kermanshah, iran mohammad reza ashrafi-kooshk medical biology research center, kermanshah university of medical sciences, kermanshah, iran mostafa rezaei-tavirani proteomics research center, faculty of paramedical sciences, shahid-beheshti university of medical sciences, tehran, iran reza khodarahmi department of pharmacognosy & biotechnology, faculty of pharmacy, kermanshah university of medical sciences, kermanshah, iran

polyphenol oxidase (ppo), also known as tyrosinase (ec 1.14.18.1), is a copper-containing enzyme widely distributed in microorganisms, animals, and plants. this enzyme is responsible not only for browning in plants but also for melanization in animals. thus, tyrosinase inhibitors have a huge impact on industry and the economy. in the current study, we first purified the enzyme, then evaluated i...

2018
Qi Li Hongyu Yang Jun Mo Yao Chen Yue Wu Chen Kang Yuan Sun Haopeng Sun

Targeting tyrosinase is considered to be an effective way to control the production of melanin. Tyrosinase inhibitor is anticipated to provide new therapy to prevent skin pigmentation, melanoma and neurodegenerative diseases. Herein, we report our results in identifying new tyrosinase inhibitors. The shape-based virtual screening was performed to discover new tyrosinase inhibitors. Thirteen pot...

Journal: :journal of biotechnology and health sciences 0
nematollah gheibi cellular and molecular research center, qazvin university of medical sciences, qazvin, ir iran nasibe yaghouby nejad department of biology, faculty of basic sciences, science and research branch, islamic azad university, tehran, ir iran mehdi sahmani department of biochemistry, school of medicine, qazvin university of medical sciences, qazvin, ir iran; department of biochemistry, school of medicine, qazvin university of medical sciences, qazvin, ir iran

background tyrosinase, as a copper-containing enzyme, is widely distributed in different levels of life span. it is also a key enzyme in melanin biosynthesis, which plays a crucial role in determining the color of mammalian skin and hair. objectives the current study aimed to determine the effect of a palladium complex on cresolase and catecholase reactions of mushroom tyrosinase (mt). material...

Journal: :Investigative ophthalmology & visual science 1978
T P Dryja M O'Neil-Dryja J M Pawelek D M Albert

Modern techniques offer an opportunity for a more complete evaluation of melanin production in the uvea and retinal pigment epithelium (RPE). By measuring the release of tritium from tritiated tyrosine in homogenized samples of adult bovine RPE as well as iris and choroid, tyrosinase activity could be demonstrated in both the uveal tract and the RPE. Phenylthiourea, a specific tyrosinase inhibi...

2017
You-Mie Lee Jun-Goo Jee

In this study, we repositioned thiopurine drugs used for the treatment of acute 12 leukaemia as new tyrosinase inhibitors. Tyrosinase catalyses two distinct and successive 13 oxidations in melanin biosynthesis: the conversions of tyrosine to dihydroxyphenylalanine (DOPA) 14 and DOPA to dopaquinone. Continuous efforts are underway to discover small molecule 15 inhibitors of tyrosinase for therap...

2017
Joonhyeok Choi You-Mie Lee Jun-Goo Jee

Drug repositioning is the application of the existing drugs to new uses and has the potential to reduce the time and cost required for the typical drug discovery process. In this study, we repositioned thiopurine drugs used for the treatment of acute leukaemia as new tyrosinase inhibitors. Tyrosinase catalyses two successive oxidations in melanin biosynthesis: the conversions of tyrosine to dih...

Journal: :Molecules 2017
You Chul Chung Seoyeon Kim Jin Hwa Kim Geun Soo Lee Jung No Lee Nam Ho Lee Chang-Gu Hyun

Tyrosinase is the rate-limiting enzyme critical for melanin synthesis. It controls pigmentation in the skin. Activation of tyrosinase is currently the most common approach in the development of tanning and haircare products. Pratol is a 7-hydroxy-4-methoxyflavone found in Trifoliumpratense. In this study, we investigated the effects of pratol on melanogenesis. We also studied the mechanism of a...

Journal: :Chemical communications 2011
Tae-Il Kim Jihye Park Seonhwa Park Yongdoo Choi Youngmi Kim

We have presented a fluorescent probe 1 that exhibits a fluorescence turn-on signal upon reaction with tyrosinase, and we show that it is readily employed for the assessment of tyrosinase activity and tyrosinase inhibitor activity in buffered aqueous solution, and further utilized for the visualization of endogenous tyrosinase activity in living melanoma cells.

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