نتایج جستجو برای: tumorigenicity
تعداد نتایج: 4632 فیلتر نتایج به سال:
Abstract Background Previous studies demonstrated the dependence of cancer on nerve. Recently, a growing number reveal that cells share property and regulatory network with neural stem/progenitor cells. However, relationship between stemness cell tumorigenicity is unknown. Results We show cells, but not non-neural embryonic or somatic types, exhibit potential for differentiation into tissue typ...
objective: it is hypothesized that stem cells have the capability to form tumors after transplantation. spermatogonial stem cells have proliferation potency and colonization ability related to express pluripotency genes such as c-myc. the primary aim of this study is to investigate tumorigenicity ability of these cells after in vitro cultivation and inoculation in athymic animals. methods: sper...
BALB/c 3T3 cells transformed in vitro with a temperature-sensitive mutant of polyoma virus were cloned. Forty-eight clones examined demonstrated heterogeneity with respect to doubling-time in vitro and tumorigenicity in syngeneic mice in vivo. Observation periods that lasted in certain cases as long as 2 years showed that some clones exhibited a relatively high tumorigenicity, i.e., they yielde...
Huang et al. (2021) identified a mechanism acting through the arginine methyltransferase PRMT6 that stabilizes interaction of RCC1 with chromatin, promoting cell proliferation and tumorigenicity. Targeting this might enhance treatment tumors such as glioblastoma.
The applicability of machine learning-based analysis in the field biomedical has been very beneficial determining biological mechanism and validation for a wide range scenarios. This approach is also gaining momentum various stem cells research activities, specifically characterization differentiation pattern. adoption similar computational approaches to study assess biosafety bioefficacy risks...
We isolated hybrids and cybrids using HeLaTG cells and human normal primary fibroblasts to examine the functional differences between the mitochondrial genomes of tumor and normal cells with respect to their possible involvement in the regulation of tumorigenicity. Hybrids contained mitochondrial DNA (mtDNA) predominantly from the fibroblast parent and their tumorigenicity was suppressed comple...
The naked mole-rat (NMR, Heterocephalus glaber), which is the longest-lived rodent species, exhibits extraordinary resistance to cancer. Here we report that NMR somatic cells exhibit a unique tumour-suppressor response to reprogramming induction. In this study, we generate NMR-induced pluripotent stem cells (NMR-iPSCs) and find that NMR-iPSCs do not exhibit teratoma-forming tumorigenicity due t...
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